Topological interaction by entangled DNA loops

Lang Feng, Ruojie Sha, Nadrian Seeman, Paul M. Chaikin

Research output: Contribution to journalArticle

Abstract

We have discovered a new type of interaction between micro- or nanoscale particles that results from the entanglement of strands attached to their surfaces. Self-complementary DNA single strands on a particle can hybridize to form loops. A similar proximal particle can have its loops catenate with those of the first. Unlike conventional thermodynamic interparticle interactions, the catenation interaction is strongly history and protocol dependent, allowing for nonequilibrium particle assembly. The interactions can be controlled by an interesting combination of forces, temperature, light sensitive cross-linking and enzymatic unwinding of the topological links. This novel topological interaction may lead to new materials and phenomena such as particles strung on necklaces, confined motions on designed contours and surfaces, and colloidal Olympic gels.

Original languageEnglish (US)
Article number188301
JournalPhysical Review Letters
Volume109
Issue number18
DOIs
StatePublished - Nov 1 2012

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deoxyribonucleic acid
strands
interactions
complementary DNA
microbalances
strings
assembly
histories
gels
thermodynamics
temperature

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Topological interaction by entangled DNA loops. / Feng, Lang; Sha, Ruojie; Seeman, Nadrian; Chaikin, Paul M.

In: Physical Review Letters, Vol. 109, No. 18, 188301, 01.11.2012.

Research output: Contribution to journalArticle

Feng, Lang ; Sha, Ruojie ; Seeman, Nadrian ; Chaikin, Paul M. / Topological interaction by entangled DNA loops. In: Physical Review Letters. 2012 ; Vol. 109, No. 18.
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