Three oral formulations of methadone

A clinical and pharmacodynamic comparison

Marc Gourevitch, Diana Hartel, Peter Tenore, Katherine Freeman, Ira Marion, Joe Hecht, Joyce Lowinson

Research output: Contribution to journalArticle

Abstract

This study was done to determine whether there were any differences in subjective symptoms of opiate withdrawal or methadone pharmacodynamics among patients as they were switched between three different oral formulations of methadone. Patients enrolled in a three-way double-blind crossover trial of three methadone formulations. Subjective symptoms and pharmacodynamic measures were assessed throughout the study period. Eighteen patients were enrolled the study. No statistically significant differences in any of the pharmacodynamic parameters studied were found among the three methadone preparations. There was no significant difference among preparations in the rate and extent of rise and fall in plasma methadone levels during a 24-hour intensive sampling period. Subjective symptoms also did not correlate with methadone formulation. Intolerance to changes in methadone formulation, often observed clinically, do not appear to have a pharmacodynamic basis. Our findings support the notion that such change intolerance reflects factors other than the pharmacologic properties of the different formulations of methadone.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalJournal of Substance Abuse Treatment
Volume17
Issue number3
DOIs
StatePublished - Oct 1999

Fingerprint

Methadone
Opiate Alkaloids
Substance Withdrawal Syndrome
Cross-Over Studies

Keywords

  • Change intolerance
  • Formulation
  • Methadone
  • Pharmacodynamics
  • Withdrawal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Phychiatric Mental Health
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Three oral formulations of methadone : A clinical and pharmacodynamic comparison. / Gourevitch, Marc; Hartel, Diana; Tenore, Peter; Freeman, Katherine; Marion, Ira; Hecht, Joe; Lowinson, Joyce.

In: Journal of Substance Abuse Treatment, Vol. 17, No. 3, 10.1999, p. 237-241.

Research output: Contribution to journalArticle

Gourevitch, Marc ; Hartel, Diana ; Tenore, Peter ; Freeman, Katherine ; Marion, Ira ; Hecht, Joe ; Lowinson, Joyce. / Three oral formulations of methadone : A clinical and pharmacodynamic comparison. In: Journal of Substance Abuse Treatment. 1999 ; Vol. 17, No. 3. pp. 237-241.
@article{bb43524482ce4a2ca1303b6626be5ea8,
title = "Three oral formulations of methadone: A clinical and pharmacodynamic comparison",
abstract = "This study was done to determine whether there were any differences in subjective symptoms of opiate withdrawal or methadone pharmacodynamics among patients as they were switched between three different oral formulations of methadone. Patients enrolled in a three-way double-blind crossover trial of three methadone formulations. Subjective symptoms and pharmacodynamic measures were assessed throughout the study period. Eighteen patients were enrolled the study. No statistically significant differences in any of the pharmacodynamic parameters studied were found among the three methadone preparations. There was no significant difference among preparations in the rate and extent of rise and fall in plasma methadone levels during a 24-hour intensive sampling period. Subjective symptoms also did not correlate with methadone formulation. Intolerance to changes in methadone formulation, often observed clinically, do not appear to have a pharmacodynamic basis. Our findings support the notion that such change intolerance reflects factors other than the pharmacologic properties of the different formulations of methadone.",
keywords = "Change intolerance, Formulation, Methadone, Pharmacodynamics, Withdrawal",
author = "Marc Gourevitch and Diana Hartel and Peter Tenore and Katherine Freeman and Ira Marion and Joe Hecht and Joyce Lowinson",
year = "1999",
month = "10",
doi = "10.1016/S0740-5472(99)00008-2",
language = "English (US)",
volume = "17",
pages = "237--241",
journal = "Journal of Substance Abuse Treatment",
issn = "0740-5472",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Three oral formulations of methadone

T2 - A clinical and pharmacodynamic comparison

AU - Gourevitch, Marc

AU - Hartel, Diana

AU - Tenore, Peter

AU - Freeman, Katherine

AU - Marion, Ira

AU - Hecht, Joe

AU - Lowinson, Joyce

PY - 1999/10

Y1 - 1999/10

N2 - This study was done to determine whether there were any differences in subjective symptoms of opiate withdrawal or methadone pharmacodynamics among patients as they were switched between three different oral formulations of methadone. Patients enrolled in a three-way double-blind crossover trial of three methadone formulations. Subjective symptoms and pharmacodynamic measures were assessed throughout the study period. Eighteen patients were enrolled the study. No statistically significant differences in any of the pharmacodynamic parameters studied were found among the three methadone preparations. There was no significant difference among preparations in the rate and extent of rise and fall in plasma methadone levels during a 24-hour intensive sampling period. Subjective symptoms also did not correlate with methadone formulation. Intolerance to changes in methadone formulation, often observed clinically, do not appear to have a pharmacodynamic basis. Our findings support the notion that such change intolerance reflects factors other than the pharmacologic properties of the different formulations of methadone.

AB - This study was done to determine whether there were any differences in subjective symptoms of opiate withdrawal or methadone pharmacodynamics among patients as they were switched between three different oral formulations of methadone. Patients enrolled in a three-way double-blind crossover trial of three methadone formulations. Subjective symptoms and pharmacodynamic measures were assessed throughout the study period. Eighteen patients were enrolled the study. No statistically significant differences in any of the pharmacodynamic parameters studied were found among the three methadone preparations. There was no significant difference among preparations in the rate and extent of rise and fall in plasma methadone levels during a 24-hour intensive sampling period. Subjective symptoms also did not correlate with methadone formulation. Intolerance to changes in methadone formulation, often observed clinically, do not appear to have a pharmacodynamic basis. Our findings support the notion that such change intolerance reflects factors other than the pharmacologic properties of the different formulations of methadone.

KW - Change intolerance

KW - Formulation

KW - Methadone

KW - Pharmacodynamics

KW - Withdrawal

UR - http://www.scopus.com/inward/record.url?scp=0032887764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032887764&partnerID=8YFLogxK

U2 - 10.1016/S0740-5472(99)00008-2

DO - 10.1016/S0740-5472(99)00008-2

M3 - Article

VL - 17

SP - 237

EP - 241

JO - Journal of Substance Abuse Treatment

JF - Journal of Substance Abuse Treatment

SN - 0740-5472

IS - 3

ER -