Three dimensional optical coherence tomography imaging: Advantages and advances

Michelle L. Gabriele, Gadi Wollstein, Hiroshi Ishikawa, Juan Xu, Jongsick Kim, Larry Kagemann, Lindsey S. Folio, Joel S. Schuman

    Research output: Contribution to journalReview article

    Abstract

    Three dimensional (3D) ophthalmic imaging using optical coherence tomography (OCT) has revolutionized assessment of the eye, the retina in particular. Recent technological improvements have made the acquisition of 3D-OCT datasets feasible. However, while volumetric data can improve disease diagnosis and follow-up, novel image analysis techniques are now necessary in order to process the dense 3D-OCT dataset. Fundamental software improvements include methods for correcting subject eye motion, segmenting structures or volumes of interest, extracting relevant data post hoc and signal averaging to improve delineation of retinal layers. In addition, innovative methods for image display, such as C-mode sectioning, provide a unique viewing perspective and may improve interpretation of OCT images of pathologic structures. While all of these methods are being developed, most remain in an immature state. This review describes the current status of 3D-OCT scanning and interpretation, and discusses the need for standardization of clinical protocols as well as the potential benefits of 3D-OCT scanning that could come when software methods for fully exploiting these rich datasets are available clinically. The implications of new image analysis approaches include improved reproducibility of measurements garnered from 3D-OCT, which may then help improve disease discrimination and progression detection. In addition, 3D-OCT offers the potential for preoperative surgical planning and intraoperative surgical guidance.

    Original languageEnglish (US)
    Pages (from-to)556-579
    Number of pages24
    JournalProgress in Retinal and Eye Research
    Volume29
    Issue number6
    DOIs
    StatePublished - Nov 1 2010

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    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems

    Cite this

    Gabriele, M. L., Wollstein, G., Ishikawa, H., Xu, J., Kim, J., Kagemann, L., Folio, L. S., & Schuman, J. S. (2010). Three dimensional optical coherence tomography imaging: Advantages and advances. Progress in Retinal and Eye Research, 29(6), 556-579. https://doi.org/10.1016/j.preteyeres.2010.05.005