Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

Vijay S. Pande, Alexander Y. Grosberg, Toyoichi Tanaka

    Research output: Contribution to journalArticle

    Abstract

    We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an 'active site' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

    Original languageEnglish (US)
    Pages (from-to)12976-12979
    Number of pages4
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume91
    Issue number26
    DOIs
    StatePublished - Dec 20 1994

    Fingerprint

    Thermodynamics
    Prebiotics
    Computer Simulation
    Catalytic Domain
    Polymers
    Proteins
    In Vitro Techniques

    Keywords

    • molecular recognition
    • renaturation

    ASJC Scopus subject areas

    • Genetics
    • General

    Cite this

    Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule. / Pande, Vijay S.; Grosberg, Alexander Y.; Tanaka, Toyoichi.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 26, 20.12.1994, p. 12976-12979.

    Research output: Contribution to journalArticle

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