Therapeutic options for lowering LDL-C in type 2 diabetes

a nurse practitioner's perspective

Kelley N ewlin Lew, Daniel J. Kent, Angelica A. Muñoz, Gail D'Eramo Melkus

Research output: Contribution to journalArticle

Abstract

PURPOSE: The majority of patients with type 2 diabetes mellitus (T2DM) have multiple risk factors for cardiovascular disease (CVD). Low-density lipoprotein cholesterol (LDL-C) is a key therapeutic target to reduce CVD risk. This article reviews therapeutic strategies that nurse practitioners (NPs) may use in the management of patients with T2DM requiring lipid management.

DATA SOURCES: The evidence used in developing this review included evidence-based reviews, clinical trials, guidelines, and consensus statements. Relevant publications were identified through a search of the literature using PubMed and other search engines.

CONCLUSIONS: Lowering LDL-C levels may reduce CVD risk, but achieving goals can be challenging. Lifestyle modifications (including diet, exercise, and smoking cessation) are key components of lipid management and reduction of CVD risk. Statins can be effective to reduce lipids. However, patients may not achieve lipid goals with monotherapy or may experience intolerable adverse effects. Alternative statins or statins along with other lipid-lowering agents remain good options.

IMPLICATIONS FOR PRACTICE: Achieving LDL-C goals requires a comprehensive treatment plan that incorporates lifestyle and pharmacologic interventions. Patient commitment in setting goals and self-management is essential. NPs can play an important role in educating patients as well as prescribing appropriate treatments.

Original languageEnglish (US)
Pages (from-to)488-494
Number of pages7
JournalJournal of the American Association of Nurse Practitioners
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2013

Fingerprint

Nurse Practitioners
LDL Cholesterol
Type 2 Diabetes Mellitus
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipids
Cardiovascular Diseases
Life Style
Diet Therapy
Therapeutics
Search Engine
Smoking Cessation
Self Care
PubMed
Publications
Consensus
Clinical Trials
Guidelines
Exercise

Keywords

  • Diabetes type 2
  • lifestyle
  • low-density lipoprotein cholesterol
  • pharmacotherapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Therapeutic options for lowering LDL-C in type 2 diabetes : a nurse practitioner's perspective. / Lew, Kelley N ewlin; Kent, Daniel J.; Muñoz, Angelica A.; D'Eramo Melkus, Gail.

In: Journal of the American Association of Nurse Practitioners, Vol. 25, No. 9, 01.09.2013, p. 488-494.

Research output: Contribution to journalArticle

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