Therapeutic high-frequency stimulation of the subthalamic nucleus in Parkinson's disease produces global increases in cerebral blood flow

John J. Sidtis, Michele Tagliati, Ron Alterman, Diana Sidtis, Vijay Dhawan, David Eidelberg

Research output: Contribution to journalArticle

Abstract

Chronic, high-frequency electrical stimulation of the subthalamic nuclei (STNs) has become an effective and widely used therapy in Parkinson's disease (PD), but the therapeutic mechanism is not understood. Stimulation of the STN is believed to reorganize neurophysiological activity patterns within the basal ganglia, whereas local field effects extending to tracts adjacent to the STN are viewed as sources of nontherapeutic side effects. This study is part of a larger project investigating the effects of STN stimulation on speech and regional cerebral blood flow (CBF) in human subjects with PD. While generating measures of global CBF (gCBF) to normalize regional CBF values for a subsequent combined analysis of regional CBF and speech data, we observed a third effect of this therapy: a gCBF increase. This effect was present across three estimates of gCBF ranging from values based on the highest activity voxels to those based on all voxels. The magnitude of the gCBF increase was related to the subject's duration of PD. It is not clear whether this CBF effect has a therapeutic role, but the impact of deep brain stimulation on cerebrovascular control warrants study from neuroscience, pathophysiological, and therapeutic perspectives.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Cerebrovascular Circulation
Subthalamic Nucleus
Parkinson Disease
Regional Blood Flow
Therapeutics
Deep Brain Stimulation
Neurosciences
Basal Ganglia
Electric Stimulation

Keywords

  • deep brain stimulation
  • movement disorder
  • Parkinson's disease
  • positron emission tomography
  • subthalamic nucleus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Therapeutic high-frequency stimulation of the subthalamic nucleus in Parkinson's disease produces global increases in cerebral blood flow. / Sidtis, John J.; Tagliati, Michele; Alterman, Ron; Sidtis, Diana; Dhawan, Vijay; Eidelberg, David.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, No. 1, 01.2012, p. 41-49.

Research output: Contribution to journalArticle

Sidtis, John J. ; Tagliati, Michele ; Alterman, Ron ; Sidtis, Diana ; Dhawan, Vijay ; Eidelberg, David. / Therapeutic high-frequency stimulation of the subthalamic nucleus in Parkinson's disease produces global increases in cerebral blood flow. In: Journal of Cerebral Blood Flow and Metabolism. 2012 ; Vol. 32, No. 1. pp. 41-49.
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