The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface

David R. Allred, Jane M R Carlton, Ryan L. Satcher, Jennifer A. Long, Wendy C. Brown, Paula E. Patterson, Roberta M. O'Connor, Suzanne E. Stroup

Research output: Contribution to journalArticle

Abstract

B. bovis, an intraerythrocytic protozoal parasite, establishes chronic infections in cattle in part through rapid variation of the polymorphic, heterodimeric VESA1 protein on the infected erythrocyte surface and sequestration of mature parasites. We describe the characterization of the ves1α gene encoding the VESA1a subunit, thus providing a description of a gene whose product is involved in rapid antigenic variation in a babesial parasite. This three-exon gene, a member of a multigene family (ves), encodes a polypeptide with no cleavable signal sequence, a single predicted transmembrane segment, and a cysteine/lysine-rich domain. Variation appears to involve creation and modification or loss of a novel, transcribed copy of the gene.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalMolecular Cell
Volume5
Issue number1
StatePublished - Jan 2000

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Antigenic Variation
Multigene Family
Erythrocytes
Parasites
Genes
Protein Sorting Signals
Lysine
Cysteine
Exons
Peptides
Infection
Proteins

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Allred, D. R., Carlton, J. M. R., Satcher, R. L., Long, J. A., Brown, W. C., Patterson, P. E., ... Stroup, S. E. (2000). The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface. Molecular Cell, 5(1), 153-162.

The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface. / Allred, David R.; Carlton, Jane M R; Satcher, Ryan L.; Long, Jennifer A.; Brown, Wendy C.; Patterson, Paula E.; O'Connor, Roberta M.; Stroup, Suzanne E.

In: Molecular Cell, Vol. 5, No. 1, 01.2000, p. 153-162.

Research output: Contribution to journalArticle

Allred, DR, Carlton, JMR, Satcher, RL, Long, JA, Brown, WC, Patterson, PE, O'Connor, RM & Stroup, SE 2000, 'The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface', Molecular Cell, vol. 5, no. 1, pp. 153-162.
Allred, David R. ; Carlton, Jane M R ; Satcher, Ryan L. ; Long, Jennifer A. ; Brown, Wendy C. ; Patterson, Paula E. ; O'Connor, Roberta M. ; Stroup, Suzanne E. / The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface. In: Molecular Cell. 2000 ; Vol. 5, No. 1. pp. 153-162.
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