The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

Jessica L. Banko, Francis Poulin, Lingfei Hou, Christine T. DeMaria, Nahum Sonenberg, Eric Klann

Research output: Contribution to journalArticle

Abstract

Long-lasting synaptic plasticity and memory requires mRNA translation, yet little is known as to how this process is regulated. To explore the role that the translation repressor 4E-BP2 plays in hippocampal long-term potentiation (LTP) and learning and memory, we examined 4E-BP2 knock-out mice. Interestingly, genetic elimination of 4E-BP2 converted early-phase LTP to late-phase LTP (L-LTP) in the Schaffer collateral pathway, likely as a result of increased eIF4F complex formation and translation initiation. A critical limit for activity-induced translation was revealed in the 4E-BP2 knock-out mice because L-LTP elicited by traditional stimulation paradigms was obstructed. Moreover, the 4E-BP2 knock-out mice also exhibited impaired spatial learning and memory and conditioned fear-associative memory deficits. These results suggest a crucial role for proper regulation of the eIF4F complex by 4E-BP2 during LTP and learning and memory in the mouse hippocampus.

Original languageEnglish (US)
Pages (from-to)9581-9590
Number of pages10
JournalJournal of Neuroscience
Volume25
Issue number42
DOIs
StatePublished - Oct 19 2005

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Neuronal Plasticity
Long-Term Potentiation
Hippocampus
Knockout Mice
Long-Term Memory
Learning
Memory Disorders
Protein Biosynthesis
Fear

Keywords

  • Fear conditioning
  • Hippocampus
  • Learning and memory
  • LTP
  • Morris water maze
  • Protein synthesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. / Banko, Jessica L.; Poulin, Francis; Hou, Lingfei; DeMaria, Christine T.; Sonenberg, Nahum; Klann, Eric.

In: Journal of Neuroscience, Vol. 25, No. 42, 19.10.2005, p. 9581-9590.

Research output: Contribution to journalArticle

Banko, Jessica L. ; Poulin, Francis ; Hou, Lingfei ; DeMaria, Christine T. ; Sonenberg, Nahum ; Klann, Eric. / The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 42. pp. 9581-9590.
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