The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites

Zbynek Bozdech, Sachel Mok, Guangan Hu, Mallika Imwong, Anchalee Jaidee, Bruce Russell, Hagai Ginsburg, Francois Nosten, Nicholas P J Day, Nicholas J. White, Jane M. Carlton, Peter R. Preiser

Research output: Contribution to journalArticle

Abstract

Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct P. vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to P. falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)16290-16295
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number42
DOIs
StatePublished - Oct 21 2008

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Plasmodium vivax
Transcriptome
Malaria
Parasites
Host-Pathogen Interactions
Gene Expression
Virulence
Infection
Proteins
Therapeutics

Keywords

  • Comparative genomics
  • Plasmodium falciparum

ASJC Scopus subject areas

  • General

Cite this

The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. / Bozdech, Zbynek; Mok, Sachel; Hu, Guangan; Imwong, Mallika; Jaidee, Anchalee; Russell, Bruce; Ginsburg, Hagai; Nosten, Francois; Day, Nicholas P J; White, Nicholas J.; Carlton, Jane M.; Preiser, Peter R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 42, 21.10.2008, p. 16290-16295.

Research output: Contribution to journalArticle

Bozdech, Zbynek ; Mok, Sachel ; Hu, Guangan ; Imwong, Mallika ; Jaidee, Anchalee ; Russell, Bruce ; Ginsburg, Hagai ; Nosten, Francois ; Day, Nicholas P J ; White, Nicholas J. ; Carlton, Jane M. ; Preiser, Peter R. / The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 42. pp. 16290-16295.
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