The time of tumor cell division and death depends on the site of growth

Lucas Luis Colombo, Esteban O. Mazzoni, Roberto Pablo Meiss

Research output: Contribution to journalArticle

Abstract

We show here, for the first time, in two very different murine tumors, a mammary one (ectoderm) and a lung one (endoderm), that: tumors have day/night differences of spontaneous apoptosis additional to the well-known circadian rhythm of mitosis. The times of maximal and minimal mitosis and apoptosis changed for a tumor cell line when growing in different organs (as metastasis) or anatomical sites. Both tumor lines, have identical circadian curves when growing in a specific organ or anatomical site. The peaks of apoptosis match with the valleys of mitosis and vice versa.

Original languageEnglish (US)
Pages (from-to)1363-1366
Number of pages4
JournalOncology Reports
Volume7
Issue number6
StatePublished - 2000

Fingerprint

Mitosis
Cell Division
Cell Death
Apoptosis
Growth
Neoplasms
Endoderm
Ectoderm
Circadian Rhythm
Tumor Cell Line
Breast
Neoplasm Metastasis
Lung

Keywords

  • Apoptosis
  • Cell death
  • Circadian rhythm
  • Metastasis
  • Mitosis
  • Organ microenvironment
  • Tumor growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The time of tumor cell division and death depends on the site of growth. / Colombo, Lucas Luis; Mazzoni, Esteban O.; Meiss, Roberto Pablo.

In: Oncology Reports, Vol. 7, No. 6, 2000, p. 1363-1366.

Research output: Contribution to journalArticle

Colombo, Lucas Luis ; Mazzoni, Esteban O. ; Meiss, Roberto Pablo. / The time of tumor cell division and death depends on the site of growth. In: Oncology Reports. 2000 ; Vol. 7, No. 6. pp. 1363-1366.
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