The shikimate pathway and its branches in apicomplexan parasites

Craig W. Roberts, Fiona Roberts, Russell E. Lyons, Michael J. Kirisits, Ernest J. Mui, John Finnerty, Jennifer J. Johnson, David J P Ferguson, John R. Coggins, Tino Krell, Graham H. Coombs, Wilbur K. Milhous, Dennis E. Kyle, Saul Tzipori, John Barnwell, John B. Dame, Jane Carlton, Rima McLeod

Research output: Contribution to journalArticle

Abstract

The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume185
Issue numberSUPPL. 1
DOIs
StatePublished - Feb 15 2002

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Parasites
glyphosate
Cryptosporidium parvum
Aromatic Amino Acids
Ubiquinone
Toxoplasma
Plasmodium falciparum
Anti-Infective Agents
Pyruvic Acid
Phenylalanine
Folic Acid
Tryptophan
Tyrosine
Fungi
Bacteria
Enzymes
Growth
erythrose 4-phosphate

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Roberts, C. W., Roberts, F., Lyons, R. E., Kirisits, M. J., Mui, E. J., Finnerty, J., ... McLeod, R. (2002). The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases, 185(SUPPL. 1). https://doi.org/10.1086/338004

The shikimate pathway and its branches in apicomplexan parasites. / Roberts, Craig W.; Roberts, Fiona; Lyons, Russell E.; Kirisits, Michael J.; Mui, Ernest J.; Finnerty, John; Johnson, Jennifer J.; Ferguson, David J P; Coggins, John R.; Krell, Tino; Coombs, Graham H.; Milhous, Wilbur K.; Kyle, Dennis E.; Tzipori, Saul; Barnwell, John; Dame, John B.; Carlton, Jane; McLeod, Rima.

In: Journal of Infectious Diseases, Vol. 185, No. SUPPL. 1, 15.02.2002.

Research output: Contribution to journalArticle

Roberts, CW, Roberts, F, Lyons, RE, Kirisits, MJ, Mui, EJ, Finnerty, J, Johnson, JJ, Ferguson, DJP, Coggins, JR, Krell, T, Coombs, GH, Milhous, WK, Kyle, DE, Tzipori, S, Barnwell, J, Dame, JB, Carlton, J & McLeod, R 2002, 'The shikimate pathway and its branches in apicomplexan parasites', Journal of Infectious Diseases, vol. 185, no. SUPPL. 1. https://doi.org/10.1086/338004
Roberts CW, Roberts F, Lyons RE, Kirisits MJ, Mui EJ, Finnerty J et al. The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases. 2002 Feb 15;185(SUPPL. 1). https://doi.org/10.1086/338004
Roberts, Craig W. ; Roberts, Fiona ; Lyons, Russell E. ; Kirisits, Michael J. ; Mui, Ernest J. ; Finnerty, John ; Johnson, Jennifer J. ; Ferguson, David J P ; Coggins, John R. ; Krell, Tino ; Coombs, Graham H. ; Milhous, Wilbur K. ; Kyle, Dennis E. ; Tzipori, Saul ; Barnwell, John ; Dame, John B. ; Carlton, Jane ; McLeod, Rima. / The shikimate pathway and its branches in apicomplexan parasites. In: Journal of Infectious Diseases. 2002 ; Vol. 185, No. SUPPL. 1.
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