The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: Progress to date and new avenues for discovery

Bradley E. Aouizerat, C. Leigh Pearce, Christine Miaskowski

Research output: Contribution to journalReview article

Abstract

Though pursuit of host genetic factors that influence the pathogenesis of HIV began over two decades ago, progress has been slow. Initial genome-level searches for variations associated with HIV-related traits have yielded interesting candidates, but less in the way of novel pathways to be exploited for therapeutic targets. More recent genome-wide association studies (GWAS) that include different phenotypes, novel designs, and that have examined different population characteristics suggest novel targets and affirm the utility of additional searches. Recent findings from these GWAS are reviewed, new directions for research are identified, and the promise of systems biology to yield novel insights is discussed.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalCurrent HIV/AIDS Reports
Volume8
Issue number1
DOIs
StatePublished - Mar 1 2011

    Fingerprint

Keywords

  • Disease progression
  • GWAS
  • Genome-wide association study
  • SNP
  • Single nucleotide polymorphism
  • Viral load set point

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this