The scaling of human osteocyte lacuna density with body size and metabolism

Timothy Bromage, Yusuf M. Juwayeyi, Julia A. Katris, Santiago Gomez, Olexandra Ovsiy, Justin Goldstein, Malvin N. Janal, Bin Hu, Friedemann Schrenk

Research output: Contribution to journalArticle

Abstract

The aim of our research is to document osteocyte lacuna density (OCD) and its biological significance among humans of known life history. Twelve human midshaft femurs obtained from sub-Saharan Africans (Malawi) of Bantu origin and known life history were prepared for backscattered electron microscopy in the scanning electron microscope (BSE-SEM). Lacunae have a characteristic size and aspect ratio in BSE-SEM images that allowed them to be identified and automatically enumerated relative to the detected bone area in all of the images processed; values for adult whole femoral midshaft cross sections averaged about 100,000 osteocyte lacunae. Statistical tests reveal significant relationships between both OCD and osteocyte lacuna area with body height. It appears that the same increase in energetic efficiency observed in interspecific comparisons of the mass specific metabolic rate of bone at larger body sizes also characterizes body size categories among humans. Long period biological rhythms that regulate rates of cell proliferation explain some aspects of human body size variability.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalComptes Rendus - Palevol
Volume15
Issue number1-2
DOIs
StatePublished - Jan 1 2016

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body size
metabolism
electron microscopy
bone
life history
biological rhythm
electron
energetics
cross section
rate
test
comparison
document
human body

Keywords

  • Body size
  • Cell proliferation
  • Havers-Halberg oscillation
  • Metabolism
  • Multidien rhythm
  • Osteocyte lacunae density

ASJC Scopus subject areas

  • Palaeontology

Cite this

Bromage, T., Juwayeyi, Y. M., Katris, J. A., Gomez, S., Ovsiy, O., Goldstein, J., ... Schrenk, F. (2016). The scaling of human osteocyte lacuna density with body size and metabolism. Comptes Rendus - Palevol, 15(1-2), 33-40. https://doi.org/10.1016/j.crpv.2015.09.001

The scaling of human osteocyte lacuna density with body size and metabolism. / Bromage, Timothy; Juwayeyi, Yusuf M.; Katris, Julia A.; Gomez, Santiago; Ovsiy, Olexandra; Goldstein, Justin; Janal, Malvin N.; Hu, Bin; Schrenk, Friedemann.

In: Comptes Rendus - Palevol, Vol. 15, No. 1-2, 01.01.2016, p. 33-40.

Research output: Contribution to journalArticle

Bromage, T, Juwayeyi, YM, Katris, JA, Gomez, S, Ovsiy, O, Goldstein, J, Janal, MN, Hu, B & Schrenk, F 2016, 'The scaling of human osteocyte lacuna density with body size and metabolism', Comptes Rendus - Palevol, vol. 15, no. 1-2, pp. 33-40. https://doi.org/10.1016/j.crpv.2015.09.001
Bromage, Timothy ; Juwayeyi, Yusuf M. ; Katris, Julia A. ; Gomez, Santiago ; Ovsiy, Olexandra ; Goldstein, Justin ; Janal, Malvin N. ; Hu, Bin ; Schrenk, Friedemann. / The scaling of human osteocyte lacuna density with body size and metabolism. In: Comptes Rendus - Palevol. 2016 ; Vol. 15, No. 1-2. pp. 33-40.
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