The roles of MAPK cascades in synaptic plasticity and memory in Aplysia

Facilitatory effects and inhibitory constraints

Shiv K. Sharma, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Synaptic plasticity is thought to contribute to memory formation. Serotonin-induced facilitation of sensory-motor (SN-MN) synapses in Aplysia is an extensively studied cellular analog of memory for sensitization. Serotonin, a modulatory neurotransmitter, is released in the CNS during sensitization training, and induces three temporally and mechanistically distinct phases of SN-MN synaptic facilitation. The role of protein kinase A and protein kinase C in SN-MN synaptic facilitation is well documented. Recently, it has become clear that mitogen-activated protein kinase (MAPK) cascades also play a critical role in SN-MN plasticity. Here, we summarize the roles of MAPK cascades in synaptic plasticity and memory for sensitization in Aplysia.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalLearning and Memory
Volume11
Issue number4
DOIs
StatePublished - Jul 2004

Fingerprint

Aplysia
Neuronal Plasticity
Mitogen-Activated Protein Kinases
Serotonin
Cyclic AMP-Dependent Protein Kinases
Synapses
Protein Kinase C
Neurotransmitter Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The roles of MAPK cascades in synaptic plasticity and memory in Aplysia : Facilitatory effects and inhibitory constraints. / Sharma, Shiv K.; Carew, Thomas.

In: Learning and Memory, Vol. 11, No. 4, 07.2004, p. 373-378.

Research output: Contribution to journalArticle

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