The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

Shoshana Yakar, Derek LeRoith, Pnina Brodt

Research output: Contribution to journalArticle

Abstract

Over the past two decades it has become widely appreciated that a relationship exists between the insulin-like growth factors (IGFs) and cancer. Many cancers have been shown to overexpress the IGF-I receptor and produce the ligands (IGF-I or IGF-II) and some combinations of the six IGF-binding proteins. With the recent demonstration by epidemiological studies that an elevated serum IGF-I level is associated with an increased relative risk of developing a number of epithelial cancers, interest has been sparked in this area of research with the possibility of targeting the IGF-I receptor in cancer treatment protocols. This review highlights many of the most relevant studies in this exciting area of research, focusing in particular on lessons learned from animal models of cancer.

Original languageEnglish (US)
Pages (from-to)407-420
Number of pages14
JournalCytokine and Growth Factor Reviews
Volume16
Issue number4-5
DOIs
StatePublished - Aug 2005

Fingerprint

IGF Type 1 Receptor
Somatomedins
Insulin-Like Growth Factor I
Growth Hormone
Tumors
Animals
Animal Models
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor II
Oncology
Growth
Antineoplastic Protocols
Neoplasms
Demonstrations
Ligands
Research
Epidemiologic Studies
Serum

Keywords

  • Cancer
  • Insulin-like growth factor
  • Mouse models
  • Receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Cite this

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression : Lessons from animal models. / Yakar, Shoshana; LeRoith, Derek; Brodt, Pnina.

In: Cytokine and Growth Factor Reviews, Vol. 16, No. 4-5, 08.2005, p. 407-420.

Research output: Contribution to journalArticle

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