The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

Jonathan M. Bekisz, Christopher D. Lopez, Carmen Corciulo, Aranzazu Mediero, Paulo Coelho, Lukasz Witek, Roberto L. Flores, Bruce N. Cronstein

Research output: Contribution to journalArticle

Abstract

Abstract: Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine’s role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis. It also reports on all the modalities reported for delivery of adenosine through in vivo applications.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalInflammation
DOIs
StateAccepted/In press - Apr 14 2018

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Purinergic P1 Receptors
Adenosine
Chondrocytes
Inflammation
Osteoarthritis
Cartilage
Homeostasis
Articular Cartilage
Ligation
Regeneration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bekisz, J. M., Lopez, C. D., Corciulo, C., Mediero, A., Coelho, P., Witek, L., ... Cronstein, B. N. (Accepted/In press). The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation. Inflammation, 1-7. https://doi.org/10.1007/s10753-018-0781-z

The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation. / Bekisz, Jonathan M.; Lopez, Christopher D.; Corciulo, Carmen; Mediero, Aranzazu; Coelho, Paulo; Witek, Lukasz; Flores, Roberto L.; Cronstein, Bruce N.

In: Inflammation, 14.04.2018, p. 1-7.

Research output: Contribution to journalArticle

Bekisz, Jonathan M. ; Lopez, Christopher D. ; Corciulo, Carmen ; Mediero, Aranzazu ; Coelho, Paulo ; Witek, Lukasz ; Flores, Roberto L. ; Cronstein, Bruce N. / The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation. In: Inflammation. 2018 ; pp. 1-7.
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