The robustness continuum

Sasha F. Levy, Mark Siegal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Organisms are subject to random changes in their external environments, as well as in their internal components. A central goal of evolutionary systems biology is to understand how living systems cope withand in some cases exploitthis variation. Many cellular and developmental processes operate with high fidelity to produce stereotyped, irreversible outcomes despite environmental and genetic perturbation. These processes are said to be robust or insensitive to variation. Robustness can lead to single, invariant phenotypes, or it can take the form of phenotypic plasticity, in which different environmental conditions reproducibly induce distinct phenotypes. Some organisms cope with environmental variation not with robust responses but with stochastic, reversible fate decisions. In those organisms, lower robustness yields heterogeneity among individuals, which in turn serves as a bet-hedging mechanism for the population. Considering high-fidelity and bet-hedging processes togetheras a robustness continuumprovides a unifying framework for analyzing and conceptualizing variation in complex evolving systems. This framework can be applied to understanding the architectures and dynamics of the regulatory networks that underlie fate decisions in microbes, plants, animals, and cancer cells.

Original languageEnglish (US)
Title of host publicationEvolutionary Systems Biology
PublisherSpringer New York LLC
Pages431-452
Number of pages22
Volume751
ISBN (Print)9781461435662
DOIs
StatePublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume751
ISSN (Print)00652598

Fingerprint

Plasticity
Large scale systems
Animals
Cells
Phenotype
Systems Biology
Population
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Levy, S. F., & Siegal, M. (2012). The robustness continuum. In Evolutionary Systems Biology (Vol. 751, pp. 431-452). (Advances in Experimental Medicine and Biology; Vol. 751). Springer New York LLC. https://doi.org/10.1007/978-1-4614-3567-9_20

The robustness continuum. / Levy, Sasha F.; Siegal, Mark.

Evolutionary Systems Biology. Vol. 751 Springer New York LLC, 2012. p. 431-452 (Advances in Experimental Medicine and Biology; Vol. 751).

Research output: Chapter in Book/Report/Conference proceedingChapter

Levy, SF & Siegal, M 2012, The robustness continuum. in Evolutionary Systems Biology. vol. 751, Advances in Experimental Medicine and Biology, vol. 751, Springer New York LLC, pp. 431-452. https://doi.org/10.1007/978-1-4614-3567-9_20
Levy SF, Siegal M. The robustness continuum. In Evolutionary Systems Biology. Vol. 751. Springer New York LLC. 2012. p. 431-452. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-3567-9_20
Levy, Sasha F. ; Siegal, Mark. / The robustness continuum. Evolutionary Systems Biology. Vol. 751 Springer New York LLC, 2012. pp. 431-452 (Advances in Experimental Medicine and Biology).
@inbook{3618a72262cc453b925e2fbf260b8cc6,
title = "The robustness continuum",
abstract = "Organisms are subject to random changes in their external environments, as well as in their internal components. A central goal of evolutionary systems biology is to understand how living systems cope withand in some cases exploitthis variation. Many cellular and developmental processes operate with high fidelity to produce stereotyped, irreversible outcomes despite environmental and genetic perturbation. These processes are said to be robust or insensitive to variation. Robustness can lead to single, invariant phenotypes, or it can take the form of phenotypic plasticity, in which different environmental conditions reproducibly induce distinct phenotypes. Some organisms cope with environmental variation not with robust responses but with stochastic, reversible fate decisions. In those organisms, lower robustness yields heterogeneity among individuals, which in turn serves as a bet-hedging mechanism for the population. Considering high-fidelity and bet-hedging processes togetheras a robustness continuumprovides a unifying framework for analyzing and conceptualizing variation in complex evolving systems. This framework can be applied to understanding the architectures and dynamics of the regulatory networks that underlie fate decisions in microbes, plants, animals, and cancer cells.",
author = "Levy, {Sasha F.} and Mark Siegal",
year = "2012",
doi = "10.1007/978-1-4614-3567-9_20",
language = "English (US)",
isbn = "9781461435662",
volume = "751",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "431--452",
booktitle = "Evolutionary Systems Biology",

}

TY - CHAP

T1 - The robustness continuum

AU - Levy, Sasha F.

AU - Siegal, Mark

PY - 2012

Y1 - 2012

N2 - Organisms are subject to random changes in their external environments, as well as in their internal components. A central goal of evolutionary systems biology is to understand how living systems cope withand in some cases exploitthis variation. Many cellular and developmental processes operate with high fidelity to produce stereotyped, irreversible outcomes despite environmental and genetic perturbation. These processes are said to be robust or insensitive to variation. Robustness can lead to single, invariant phenotypes, or it can take the form of phenotypic plasticity, in which different environmental conditions reproducibly induce distinct phenotypes. Some organisms cope with environmental variation not with robust responses but with stochastic, reversible fate decisions. In those organisms, lower robustness yields heterogeneity among individuals, which in turn serves as a bet-hedging mechanism for the population. Considering high-fidelity and bet-hedging processes togetheras a robustness continuumprovides a unifying framework for analyzing and conceptualizing variation in complex evolving systems. This framework can be applied to understanding the architectures and dynamics of the regulatory networks that underlie fate decisions in microbes, plants, animals, and cancer cells.

AB - Organisms are subject to random changes in their external environments, as well as in their internal components. A central goal of evolutionary systems biology is to understand how living systems cope withand in some cases exploitthis variation. Many cellular and developmental processes operate with high fidelity to produce stereotyped, irreversible outcomes despite environmental and genetic perturbation. These processes are said to be robust or insensitive to variation. Robustness can lead to single, invariant phenotypes, or it can take the form of phenotypic plasticity, in which different environmental conditions reproducibly induce distinct phenotypes. Some organisms cope with environmental variation not with robust responses but with stochastic, reversible fate decisions. In those organisms, lower robustness yields heterogeneity among individuals, which in turn serves as a bet-hedging mechanism for the population. Considering high-fidelity and bet-hedging processes togetheras a robustness continuumprovides a unifying framework for analyzing and conceptualizing variation in complex evolving systems. This framework can be applied to understanding the architectures and dynamics of the regulatory networks that underlie fate decisions in microbes, plants, animals, and cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=84866780198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866780198&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-3567-9_20

DO - 10.1007/978-1-4614-3567-9_20

M3 - Chapter

SN - 9781461435662

VL - 751

T3 - Advances in Experimental Medicine and Biology

SP - 431

EP - 452

BT - Evolutionary Systems Biology

PB - Springer New York LLC

ER -