The retinal mosaics of opsin expression in invertebrates and vertebrates

Jens Rister, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Color vision is found in many invertebrate and vertebrate species. It is the ability to discriminate objects based on the wavelength of emitted light independent of intensity. As it requires the comparison of at least two photoreceptor types with different spectral sensitivities, this process is often mediated by a mosaic made of several photoreceptor types. In this review, we summarize the current knowledge about the formation of retinal mosaics and the regulation of photopigment (opsin) expression in the fly, mouse, and human retina. Despite distinct evolutionary origins, as well as major differences in morphology and phototransduction machineries, there are significant similarities in the stepwise cell-fate decisions that lead from progenitor cells to terminally differentiated photoreceptors that express a particular opsin. Common themes include (i) the use of binary transcriptional switches that distinguish classes of photoreceptors, (ii) the use of gradients of signaling molecules for regional specializations, (iii) stochastic choices that pattern the retina, and (iv) the use of permissive factors with multiple roles in different photoreceptor types.

Original languageEnglish (US)
Pages (from-to)1212-1226
Number of pages15
JournalDevelopmental Neurobiology
Volume71
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

Opsins
Invertebrates
Vertebrates
Retina
Light Signal Transduction
Color Vision
Aptitude
Diptera
Stem Cells
Light

Keywords

  • Color vision
  • Opsin
  • Photoreceptor
  • Retinal mosaic
  • Transcription factors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

The retinal mosaics of opsin expression in invertebrates and vertebrates. / Rister, Jens; Desplan, Claude.

In: Developmental Neurobiology, Vol. 71, No. 12, 12.2011, p. 1212-1226.

Research output: Contribution to journalArticle

@article{b63ecc2bc2f146c6b4e7135849affc55,
title = "The retinal mosaics of opsin expression in invertebrates and vertebrates",
abstract = "Color vision is found in many invertebrate and vertebrate species. It is the ability to discriminate objects based on the wavelength of emitted light independent of intensity. As it requires the comparison of at least two photoreceptor types with different spectral sensitivities, this process is often mediated by a mosaic made of several photoreceptor types. In this review, we summarize the current knowledge about the formation of retinal mosaics and the regulation of photopigment (opsin) expression in the fly, mouse, and human retina. Despite distinct evolutionary origins, as well as major differences in morphology and phototransduction machineries, there are significant similarities in the stepwise cell-fate decisions that lead from progenitor cells to terminally differentiated photoreceptors that express a particular opsin. Common themes include (i) the use of binary transcriptional switches that distinguish classes of photoreceptors, (ii) the use of gradients of signaling molecules for regional specializations, (iii) stochastic choices that pattern the retina, and (iv) the use of permissive factors with multiple roles in different photoreceptor types.",
keywords = "Color vision, Opsin, Photoreceptor, Retinal mosaic, Transcription factors",
author = "Jens Rister and Claude Desplan",
year = "2011",
month = "12",
doi = "10.1002/dneu.20905",
language = "English (US)",
volume = "71",
pages = "1212--1226",
journal = "Developmental Neurobiology",
issn = "1932-8451",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

TY - JOUR

T1 - The retinal mosaics of opsin expression in invertebrates and vertebrates

AU - Rister, Jens

AU - Desplan, Claude

PY - 2011/12

Y1 - 2011/12

N2 - Color vision is found in many invertebrate and vertebrate species. It is the ability to discriminate objects based on the wavelength of emitted light independent of intensity. As it requires the comparison of at least two photoreceptor types with different spectral sensitivities, this process is often mediated by a mosaic made of several photoreceptor types. In this review, we summarize the current knowledge about the formation of retinal mosaics and the regulation of photopigment (opsin) expression in the fly, mouse, and human retina. Despite distinct evolutionary origins, as well as major differences in morphology and phototransduction machineries, there are significant similarities in the stepwise cell-fate decisions that lead from progenitor cells to terminally differentiated photoreceptors that express a particular opsin. Common themes include (i) the use of binary transcriptional switches that distinguish classes of photoreceptors, (ii) the use of gradients of signaling molecules for regional specializations, (iii) stochastic choices that pattern the retina, and (iv) the use of permissive factors with multiple roles in different photoreceptor types.

AB - Color vision is found in many invertebrate and vertebrate species. It is the ability to discriminate objects based on the wavelength of emitted light independent of intensity. As it requires the comparison of at least two photoreceptor types with different spectral sensitivities, this process is often mediated by a mosaic made of several photoreceptor types. In this review, we summarize the current knowledge about the formation of retinal mosaics and the regulation of photopigment (opsin) expression in the fly, mouse, and human retina. Despite distinct evolutionary origins, as well as major differences in morphology and phototransduction machineries, there are significant similarities in the stepwise cell-fate decisions that lead from progenitor cells to terminally differentiated photoreceptors that express a particular opsin. Common themes include (i) the use of binary transcriptional switches that distinguish classes of photoreceptors, (ii) the use of gradients of signaling molecules for regional specializations, (iii) stochastic choices that pattern the retina, and (iv) the use of permissive factors with multiple roles in different photoreceptor types.

KW - Color vision

KW - Opsin

KW - Photoreceptor

KW - Retinal mosaic

KW - Transcription factors

UR - http://www.scopus.com/inward/record.url?scp=80455172147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80455172147&partnerID=8YFLogxK

U2 - 10.1002/dneu.20905

DO - 10.1002/dneu.20905

M3 - Article

VL - 71

SP - 1212

EP - 1226

JO - Developmental Neurobiology

JF - Developmental Neurobiology

SN - 1932-8451

IS - 12

ER -