The relationship between injection drug use risk behaviors and markers of immune activation

Sherry Deren, Charles M. Cleland, Haekyung Lee, Saurabh Mehandru, Martin Markowitz

Research output: Contribution to journalArticle


High levels of immune activation are reported for people who inject drugs. Studies of the relationship between injection behaviors and immune activation have yielded mixed results, in part due to lack of control for hepatitis C virus in analyses. This study, of 48 HIV-seronegative people who inject drugs, examines this relationship controlling for hepatitis C virus viremia. Frequency of injection was positively related to markers of immune activation (soluble CD14, %CD8+CD38+HLADR+ T cells), as was duration of injection (highspecificity C-reactive protein and D-dimer). Sharing injection equipment was not related to markers studied. Findings suggest that efforts to encourage injection cessation or reduction in frequency can have positive health benefits through reducing immune activation.

Original languageEnglish (US)
Pages (from-to)e8-e12
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number1
StatePublished - Jan 1 2017



  • HIV risk behaviors
  • Immune activation
  • Injection drug use

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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