The Relationship Between Injection Drug Use Risk Behaviors and Markers of Immune Activation

Sherry Deren, Charles M. Cleland, Haekyung Lee, Saurabh Mehandru, Martin Markowitz

Research output: Contribution to journalArticle

Abstract

ABSTRACT: High levels of immune activation are reported for people who inject drugs (PWID). Studies of the relationship between injection behaviors and immune activation have yielded mixed results, in part due to lack of control for HCV in analyses. This study, of 48 HIV-seronegative PWID, examines this relationship controlling for HCV viremia. Frequency of injection was positively related to markers of immune activation (sCD14, %CD8+CD38+HLADR+T cells), as was duration of injection (hs-CRP and D-dimer). Sharing injection equipment was not related to markers studied. Findings suggest that efforts to encourage injection cessation or reduction in frequency can have positive health benefits through reducing immune activation.

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
StateAccepted/In press - Dec 7 2016

Fingerprint

Risk-Taking
Biomarkers
Injections
Pharmaceutical Preparations
Viremia
Insurance Benefits
HIV
T-Lymphocytes
Equipment and Supplies

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

The Relationship Between Injection Drug Use Risk Behaviors and Markers of Immune Activation. / Deren, Sherry; Cleland, Charles M.; Lee, Haekyung; Mehandru, Saurabh; Markowitz, Martin.

In: Journal of Acquired Immune Deficiency Syndromes, 07.12.2016.

Research output: Contribution to journalArticle

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