The protective effect of moderate alcohol consumption on ischemic stroke

Ralph L. Sacco, Mitchell Elkind, Bernadette Boden-Albala, I. Feng Lin, Douglas E. Kargman, W. Allen Hauser, Steven Shea, Myunghee C. Paik

Research output: Contribution to journalArticle

Abstract

Context: Moderate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial. Objective: To determine the association between alcohol consumption and risk of ischemic stroke. Design: Population-based case-control study conducted between July 1993 and June 1997. Setting: Multiethnic population in northern Manhattan, New York, NY, aged 40 years or older. Patients and Other Participants: Cases (n = 677) had first ischemic stroke and were matched to community controls (n = 1139) derived through random digit dialing by age, sex, and race/ethnicity. Mean ± SD age of cases was 70.0 ± 12.7 years; 55.8% were women; 19.5% were white, 28.4% black, and 50.7% Hispanic. Main Outcome Measure: First ischemic stroke (fatal or nonfatal). Results: Moderate alcohol consumption, up to 2 drinks per day, was significantly protective for ischemic stroke after adjustment for cardiac disease, hypertension, diabetes, current smoking, body mass index, and education (odds ratio [OR], 0.51; 95% confidence interval [CI], 0.39-0.67). This protective effect of alcohol consumption was detected in both younger and older groups, in men and women, and in whites, blacks, and Hispanics. In a quadratic model of stroke risk, increased risk of ischemic stroke was statistically significant among those consuming 7 or more drinks per day (OR, 2.96; 95% CI, 1.05-8.29). Conclusions: Moderate alcohol consumption was independently associated with a decreased risk of ischemic stroke in our elderly, multiethnic, urban subjects, while heavy alcohol consumption had deleterious effects. Our data support the National Stroke Association Stroke Prevention Guidelines regarding the beneficial effects of moderate alcohol consumption.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalJAMA - Journal of the American Medical Association
Volume281
Issue number1
DOIs
StatePublished - Jan 6 1999

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Alcohol Drinking
Stroke
Hispanic Americans
Odds Ratio
Confidence Intervals
Population
Coronary Disease
Case-Control Studies
Heart Diseases
Body Mass Index
Smoking
Outcome Assessment (Health Care)
Guidelines
Hypertension
Education

ASJC Scopus subject areas

  • Medicine(all)

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The protective effect of moderate alcohol consumption on ischemic stroke. / Sacco, Ralph L.; Elkind, Mitchell; Boden-Albala, Bernadette; Lin, I. Feng; Kargman, Douglas E.; Hauser, W. Allen; Shea, Steven; Paik, Myunghee C.

In: JAMA - Journal of the American Medical Association, Vol. 281, No. 1, 06.01.1999, p. 53-60.

Research output: Contribution to journalArticle

Sacco, Ralph L. ; Elkind, Mitchell ; Boden-Albala, Bernadette ; Lin, I. Feng ; Kargman, Douglas E. ; Hauser, W. Allen ; Shea, Steven ; Paik, Myunghee C. / The protective effect of moderate alcohol consumption on ischemic stroke. In: JAMA - Journal of the American Medical Association. 1999 ; Vol. 281, No. 1. pp. 53-60.
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abstract = "Context: Moderate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial. Objective: To determine the association between alcohol consumption and risk of ischemic stroke. Design: Population-based case-control study conducted between July 1993 and June 1997. Setting: Multiethnic population in northern Manhattan, New York, NY, aged 40 years or older. Patients and Other Participants: Cases (n = 677) had first ischemic stroke and were matched to community controls (n = 1139) derived through random digit dialing by age, sex, and race/ethnicity. Mean ± SD age of cases was 70.0 ± 12.7 years; 55.8{\%} were women; 19.5{\%} were white, 28.4{\%} black, and 50.7{\%} Hispanic. Main Outcome Measure: First ischemic stroke (fatal or nonfatal). Results: Moderate alcohol consumption, up to 2 drinks per day, was significantly protective for ischemic stroke after adjustment for cardiac disease, hypertension, diabetes, current smoking, body mass index, and education (odds ratio [OR], 0.51; 95{\%} confidence interval [CI], 0.39-0.67). This protective effect of alcohol consumption was detected in both younger and older groups, in men and women, and in whites, blacks, and Hispanics. In a quadratic model of stroke risk, increased risk of ischemic stroke was statistically significant among those consuming 7 or more drinks per day (OR, 2.96; 95{\%} CI, 1.05-8.29). Conclusions: Moderate alcohol consumption was independently associated with a decreased risk of ischemic stroke in our elderly, multiethnic, urban subjects, while heavy alcohol consumption had deleterious effects. Our data support the National Stroke Association Stroke Prevention Guidelines regarding the beneficial effects of moderate alcohol consumption.",
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