The ontogeny of the laminar distribution of β-adrenergic receptors in the visual cortex of cats, normally reared and dark-reared

Chiye Aoki, David Kaufman, Thomas C. Rainbow

Research output: Contribution to journalArticle

Abstract

Patterns of distribution of β1 and β2 adrenergic receptors were examined autoradiographically in slide-mounted sections from the visual cortical areas of 22 developing cat brains, using [125I]iodopindolol as the ligand in combination with displacers specific for β1 and β2 subtypes of adrenergic receptors. Within visual cortical areas 17 and 18 of adult brains, the density of β1 and β2 adrenergic receptors was highest in laminae I-III, lowest in lamina IV, and intermediate in laminae V-VI. For β1 adrenergic receptors, this laminar distribution was also seen in visual area 19 as well as in the non-visual area 7 that is lateral to area 19. By contrast, the distribution of β2 adrenergic receptors varied across cortical areas, such that its density was more homogeneous across the laminae in area 19, and decreased in all laminae in area 7. This pattern of distribution in adult brains was already formed at the beginning of the critical period and was not disturbed by dark-rearing.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalDevelopmental Brain Research
Volume27
Issue number1
DOIs
StatePublished - Jun 1986

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Keywords

  • critical period
  • dark-rearing
  • development
  • iodopindolol
  • visual cortex
  • β-adrenergic receptor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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