The onset of visual experience gates auditory cortex critical periods

Todd M. Mowery, Vibhakar C. Kotak, Dan Sanes

Research output: Contribution to journalArticle

Abstract

Sensory systems influence one another during development and deprivation can lead to cross-modal plasticity. As auditory function begins before vision, we investigate the effect of manipulating visual experience during auditory cortex critical periods (CPs) by assessing the influence of early, normal and delayed eyelid opening on hearing loss-induced changes to membrane and inhibitory synaptic properties. Early eyelid opening closes the auditory cortex CPs precociously and dark rearing prevents this effect. In contrast, delayed eyelid opening extends the auditory cortex CPs by several additional days. The CP for recovery from hearing loss is also closed prematurely by early eyelid opening and extended by delayed eyelid opening. Furthermore, when coupled with transient hearing loss that animals normally fully recover from, very early visual experience leads to inhibitory deficits that persist into adulthood. Finally, we demonstrate a functional projection from the visual to auditory cortex that could mediate these effects.

Original languageEnglish (US)
Article number10416
JournalNature Communications
Volume7
DOIs
StatePublished - Jan 20 2016

Fingerprint

Auditory Cortex
cortexes
Audition
Eyelids
auditory defects
Hearing Loss
Plasticity
deprivation
Animals
Synaptic Membranes
Membranes
Recovery
plastic properties
animals
projection
recovery
Critical Period (Psychology)
membranes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

The onset of visual experience gates auditory cortex critical periods. / Mowery, Todd M.; Kotak, Vibhakar C.; Sanes, Dan.

In: Nature Communications, Vol. 7, 10416, 20.01.2016.

Research output: Contribution to journalArticle

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