The network collective

Rise and fall of a scientific paradigm

Klaus Eichmann, Oswald T. Avery, David Baltimore, Emil Von Behring, Baruj Benacerraf, David Bloor, Jules J B V Bordet, Constantin A. Bona, Edward A. Boyse, F. Macfarlane Burnet, Harvey Cantor, Pierre A. Cazenave, Henry N. Claman, Melvin Cohn, Antonio Coutinho, Mark M. Davis, Francis H. Crick, Theodosius G. Dobzhansky, Peter C. Doherty, Umberto Eco & 79 others Gerald M. Edelman, Paul Ehrlich, Paul Feyerabend, Ludwik Fleck, Joan Fujimura, Richard K. Gershon, Ronald N. Germain, James L. Gowans, Mark I. Greene, Ian Hacking, Felix Haurowitz, Pekka Häyry, Michael Heidelberger, Leonard N. Herzenberg, Norbert Hilschmann, Geoffrey W. Hoffmann, Leroy Hood, Kurt Hübner, David Hume, Charles A. Janeway, Cristina Joao, Niels Jerne, Elvin A. Kabat, Michel D. Kazatchkine, Shibasaburo Kitasato, Karin Knorr-Cetina, Georges J F Köhler, Heinz Köhler, Hilary Koprowski, Thomas S. Kuhn, Henry G. Kunkel, Imre Lakatos, Karl Landsteiner, Bruno Latour, Larry Laudan, Joshua Lederberg, Ronald Levy, Tak W. Mak, Philippa C. Marrack, John J. Marchalonis, Polly C E Matzinger, Hugh O. McDevitt, Peter B. Medawar, Jaques F A Miller, Cesar Milstein, N. Avrion Mitchison, Göran Möller, Alfred Nisonoff, Gustav J V Nossal, Susumu Ohno, Jacques Oudin, William E. Paul, Linus C. Pauling, Karl R. Popper, Rodney R. Porter, Michael Potter, Willard V O Quine, Martin Raff, Klaus Rajewsky, Hans Reichenbach, Scott L. Rodkey, Michael Sela, Eli E. Sercarz, Morton Simonsen, Alan Sokal, Tomio Tada, David W. Talmage, Arne W K Tiselius, Susumu Tonegawa, Thure Von Uexküll, Emil R. Unanue, Jonathan W. Uhr, Jacques Urbain, Francisco J. Varela, Nelson M. Vaz, James D. Watson, Norbert Wiener, Hans Wigzell, Rolf M. Zinkernagel

    Research output: Book/ReportBook

    Abstract

    First-hand account of the rise and fall of a scientific paradigm Shows how scientific fiction turns to fact Highlights the origin of scientific hype Includes interviews with prominent scientists The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual "idiotypic" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the "Eigenbehavior" of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an exciting new perspective of the immune system is now viewed as a scientific vagary, and is largely abandoned. The author, himself a participant in the network vagary, begins with a description of the leading theoretical concepts on fact finding in science. This is followed by a historical account of the rise and fall of the network paradigm, complemented by personal interviews with some of the prominent protagonists. By comparing the network paradigm to other, more lasting concepts in life science, the author develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality.

    Original languageEnglish (US)
    PublisherBirkhauser Verlag AG
    Number of pages274
    ISBN (Print)9783764383732, 9783764383725
    DOIs
    StatePublished - 2008

    Fingerprint

    Immune system
    immune system
    Immune System
    interviews
    Antibody Diversity
    Cybernetics
    Interviews
    Systems Biology
    Biological Science Disciplines
    Individuality
    Personality
    Biological Sciences
    Equipment and Supplies
    Antibodies
    Substrates
    Infection
    Research
    infection
    methodology

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Eichmann, K., Avery, O. T., Baltimore, D., Von Behring, E., Benacerraf, B., Bloor, D., ... Zinkernagel, R. M. (2008). The network collective: Rise and fall of a scientific paradigm. Birkhauser Verlag AG. https://doi.org/10.1007/978-3-7643-8373-2

    The network collective : Rise and fall of a scientific paradigm. / Eichmann, Klaus; Avery, Oswald T.; Baltimore, David; Von Behring, Emil; Benacerraf, Baruj; Bloor, David; Bordet, Jules J B V; Bona, Constantin A.; Boyse, Edward A.; Burnet, F. Macfarlane; Cantor, Harvey; Cazenave, Pierre A.; Claman, Henry N.; Cohn, Melvin; Coutinho, Antonio; Davis, Mark M.; Crick, Francis H.; Dobzhansky, Theodosius G.; Doherty, Peter C.; Eco, Umberto; Edelman, Gerald M.; Ehrlich, Paul; Feyerabend, Paul; Fleck, Ludwik; Fujimura, Joan; Gershon, Richard K.; Germain, Ronald N.; Gowans, James L.; Greene, Mark I.; Hacking, Ian; Haurowitz, Felix; Häyry, Pekka; Heidelberger, Michael; Herzenberg, Leonard N.; Hilschmann, Norbert; Hoffmann, Geoffrey W.; Hood, Leroy; Hübner, Kurt; Hume, David; Janeway, Charles A.; Joao, Cristina; Jerne, Niels; Kabat, Elvin A.; Kazatchkine, Michel D.; Kitasato, Shibasaburo; Knorr-Cetina, Karin; Köhler, Georges J F; Köhler, Heinz; Koprowski, Hilary; Kuhn, Thomas S.; Kunkel, Henry G.; Lakatos, Imre; Landsteiner, Karl; Latour, Bruno; Laudan, Larry; Lederberg, Joshua; Levy, Ronald; Mak, Tak W.; Marrack, Philippa C.; Marchalonis, John J.; Matzinger, Polly C E; McDevitt, Hugh O.; Medawar, Peter B.; Miller, Jaques F A; Milstein, Cesar; Mitchison, N. Avrion; Möller, Göran; Nisonoff, Alfred; Nossal, Gustav J V; Ohno, Susumu; Oudin, Jacques; Paul, William E.; Pauling, Linus C.; Popper, Karl R.; Porter, Rodney R.; Potter, Michael; Quine, Willard V O; Raff, Martin; Rajewsky, Klaus; Reichenbach, Hans; Rodkey, Scott L.; Sela, Michael; Sercarz, Eli E.; Simonsen, Morton; Sokal, Alan; Tada, Tomio; Talmage, David W.; Tiselius, Arne W K; Tonegawa, Susumu; Uexküll, Thure Von; Unanue, Emil R.; Uhr, Jonathan W.; Urbain, Jacques; Varela, Francisco J.; Vaz, Nelson M.; Watson, James D.; Wiener, Norbert; Wigzell, Hans; Zinkernagel, Rolf M.

    Birkhauser Verlag AG, 2008. 274 p.

    Research output: Book/ReportBook

    Eichmann, K, Avery, OT, Baltimore, D, Von Behring, E, Benacerraf, B, Bloor, D, Bordet, JJBV, Bona, CA, Boyse, EA, Burnet, FM, Cantor, H, Cazenave, PA, Claman, HN, Cohn, M, Coutinho, A, Davis, MM, Crick, FH, Dobzhansky, TG, Doherty, PC, Eco, U, Edelman, GM, Ehrlich, P, Feyerabend, P, Fleck, L, Fujimura, J, Gershon, RK, Germain, RN, Gowans, JL, Greene, MI, Hacking, I, Haurowitz, F, Häyry, P, Heidelberger, M, Herzenberg, LN, Hilschmann, N, Hoffmann, GW, Hood, L, Hübner, K, Hume, D, Janeway, CA, Joao, C, Jerne, N, Kabat, EA, Kazatchkine, MD, Kitasato, S, Knorr-Cetina, K, Köhler, GJF, Köhler, H, Koprowski, H, Kuhn, TS, Kunkel, HG, Lakatos, I, Landsteiner, K, Latour, B, Laudan, L, Lederberg, J, Levy, R, Mak, TW, Marrack, PC, Marchalonis, JJ, Matzinger, PCE, McDevitt, HO, Medawar, PB, Miller, JFA, Milstein, C, Mitchison, NA, Möller, G, Nisonoff, A, Nossal, GJV, Ohno, S, Oudin, J, Paul, WE, Pauling, LC, Popper, KR, Porter, RR, Potter, M, Quine, WVO, Raff, M, Rajewsky, K, Reichenbach, H, Rodkey, SL, Sela, M, Sercarz, EE, Simonsen, M, Sokal, A, Tada, T, Talmage, DW, Tiselius, AWK, Tonegawa, S, Uexküll, TV, Unanue, ER, Uhr, JW, Urbain, J, Varela, FJ, Vaz, NM, Watson, JD, Wiener, N, Wigzell, H & Zinkernagel, RM 2008, The network collective: Rise and fall of a scientific paradigm. Birkhauser Verlag AG. https://doi.org/10.1007/978-3-7643-8373-2
    Eichmann K, Avery OT, Baltimore D, Von Behring E, Benacerraf B, Bloor D et al. The network collective: Rise and fall of a scientific paradigm. Birkhauser Verlag AG, 2008. 274 p. https://doi.org/10.1007/978-3-7643-8373-2
    Eichmann, Klaus ; Avery, Oswald T. ; Baltimore, David ; Von Behring, Emil ; Benacerraf, Baruj ; Bloor, David ; Bordet, Jules J B V ; Bona, Constantin A. ; Boyse, Edward A. ; Burnet, F. Macfarlane ; Cantor, Harvey ; Cazenave, Pierre A. ; Claman, Henry N. ; Cohn, Melvin ; Coutinho, Antonio ; Davis, Mark M. ; Crick, Francis H. ; Dobzhansky, Theodosius G. ; Doherty, Peter C. ; Eco, Umberto ; Edelman, Gerald M. ; Ehrlich, Paul ; Feyerabend, Paul ; Fleck, Ludwik ; Fujimura, Joan ; Gershon, Richard K. ; Germain, Ronald N. ; Gowans, James L. ; Greene, Mark I. ; Hacking, Ian ; Haurowitz, Felix ; Häyry, Pekka ; Heidelberger, Michael ; Herzenberg, Leonard N. ; Hilschmann, Norbert ; Hoffmann, Geoffrey W. ; Hood, Leroy ; Hübner, Kurt ; Hume, David ; Janeway, Charles A. ; Joao, Cristina ; Jerne, Niels ; Kabat, Elvin A. ; Kazatchkine, Michel D. ; Kitasato, Shibasaburo ; Knorr-Cetina, Karin ; Köhler, Georges J F ; Köhler, Heinz ; Koprowski, Hilary ; Kuhn, Thomas S. ; Kunkel, Henry G. ; Lakatos, Imre ; Landsteiner, Karl ; Latour, Bruno ; Laudan, Larry ; Lederberg, Joshua ; Levy, Ronald ; Mak, Tak W. ; Marrack, Philippa C. ; Marchalonis, John J. ; Matzinger, Polly C E ; McDevitt, Hugh O. ; Medawar, Peter B. ; Miller, Jaques F A ; Milstein, Cesar ; Mitchison, N. Avrion ; Möller, Göran ; Nisonoff, Alfred ; Nossal, Gustav J V ; Ohno, Susumu ; Oudin, Jacques ; Paul, William E. ; Pauling, Linus C. ; Popper, Karl R. ; Porter, Rodney R. ; Potter, Michael ; Quine, Willard V O ; Raff, Martin ; Rajewsky, Klaus ; Reichenbach, Hans ; Rodkey, Scott L. ; Sela, Michael ; Sercarz, Eli E. ; Simonsen, Morton ; Sokal, Alan ; Tada, Tomio ; Talmage, David W. ; Tiselius, Arne W K ; Tonegawa, Susumu ; Uexküll, Thure Von ; Unanue, Emil R. ; Uhr, Jonathan W. ; Urbain, Jacques ; Varela, Francisco J. ; Vaz, Nelson M. ; Watson, James D. ; Wiener, Norbert ; Wigzell, Hans ; Zinkernagel, Rolf M. / The network collective : Rise and fall of a scientific paradigm. Birkhauser Verlag AG, 2008. 274 p.
    @book{dcebfd1c4f024e9bbeacc23d5d709b1f,
    title = "The network collective: Rise and fall of a scientific paradigm",
    abstract = "First-hand account of the rise and fall of a scientific paradigm Shows how scientific fiction turns to fact Highlights the origin of scientific hype Includes interviews with prominent scientists The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual {"}idiotypic{"} recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the {"}Eigenbehavior{"} of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an exciting new perspective of the immune system is now viewed as a scientific vagary, and is largely abandoned. The author, himself a participant in the network vagary, begins with a description of the leading theoretical concepts on fact finding in science. This is followed by a historical account of the rise and fall of the network paradigm, complemented by personal interviews with some of the prominent protagonists. By comparing the network paradigm to other, more lasting concepts in life science, the author develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality.",
    author = "Klaus Eichmann and Avery, {Oswald T.} and David Baltimore and {Von Behring}, Emil and Baruj Benacerraf and David Bloor and Bordet, {Jules J B V} and Bona, {Constantin A.} and Boyse, {Edward A.} and Burnet, {F. Macfarlane} and Harvey Cantor and Cazenave, {Pierre A.} and Claman, {Henry N.} and Melvin Cohn and Antonio Coutinho and Davis, {Mark M.} and Crick, {Francis H.} and Dobzhansky, {Theodosius G.} and Doherty, {Peter C.} and Umberto Eco and Edelman, {Gerald M.} and Paul Ehrlich and Paul Feyerabend and Ludwik Fleck and Joan Fujimura and Gershon, {Richard K.} and Germain, {Ronald N.} and Gowans, {James L.} and Greene, {Mark I.} and Ian Hacking and Felix Haurowitz and Pekka H{\"a}yry and Michael Heidelberger and Herzenberg, {Leonard N.} and Norbert Hilschmann and Hoffmann, {Geoffrey W.} and Leroy Hood and Kurt H{\"u}bner and David Hume and Janeway, {Charles A.} and Cristina Joao and Niels Jerne and Kabat, {Elvin A.} and Kazatchkine, {Michel D.} and Shibasaburo Kitasato and Karin Knorr-Cetina and K{\"o}hler, {Georges J F} and Heinz K{\"o}hler and Hilary Koprowski and Kuhn, {Thomas S.} and Kunkel, {Henry G.} and Imre Lakatos and Karl Landsteiner and Bruno Latour and Larry Laudan and Joshua Lederberg and Ronald Levy and Mak, {Tak W.} and Marrack, {Philippa C.} and Marchalonis, {John J.} and Matzinger, {Polly C E} and McDevitt, {Hugh O.} and Medawar, {Peter B.} and Miller, {Jaques F A} and Cesar Milstein and Mitchison, {N. Avrion} and G{\"o}ran M{\"o}ller and Alfred Nisonoff and Nossal, {Gustav J V} and Susumu Ohno and Jacques Oudin and Paul, {William E.} and Pauling, {Linus C.} and Popper, {Karl R.} and Porter, {Rodney R.} and Michael Potter and Quine, {Willard V O} and Martin Raff and Klaus Rajewsky and Hans Reichenbach and Rodkey, {Scott L.} and Michael Sela and Sercarz, {Eli E.} and Morton Simonsen and Alan Sokal and Tomio Tada and Talmage, {David W.} and Tiselius, {Arne W K} and Susumu Tonegawa and Uexk{\"u}ll, {Thure Von} and Unanue, {Emil R.} and Uhr, {Jonathan W.} and Jacques Urbain and Varela, {Francisco J.} and Vaz, {Nelson M.} and Watson, {James D.} and Norbert Wiener and Hans Wigzell and Zinkernagel, {Rolf M.}",
    year = "2008",
    doi = "10.1007/978-3-7643-8373-2",
    language = "English (US)",
    isbn = "9783764383732",
    publisher = "Birkhauser Verlag AG",

    }

    TY - BOOK

    T1 - The network collective

    T2 - Rise and fall of a scientific paradigm

    AU - Eichmann, Klaus

    AU - Avery, Oswald T.

    AU - Baltimore, David

    AU - Von Behring, Emil

    AU - Benacerraf, Baruj

    AU - Bloor, David

    AU - Bordet, Jules J B V

    AU - Bona, Constantin A.

    AU - Boyse, Edward A.

    AU - Burnet, F. Macfarlane

    AU - Cantor, Harvey

    AU - Cazenave, Pierre A.

    AU - Claman, Henry N.

    AU - Cohn, Melvin

    AU - Coutinho, Antonio

    AU - Davis, Mark M.

    AU - Crick, Francis H.

    AU - Dobzhansky, Theodosius G.

    AU - Doherty, Peter C.

    AU - Eco, Umberto

    AU - Edelman, Gerald M.

    AU - Ehrlich, Paul

    AU - Feyerabend, Paul

    AU - Fleck, Ludwik

    AU - Fujimura, Joan

    AU - Gershon, Richard K.

    AU - Germain, Ronald N.

    AU - Gowans, James L.

    AU - Greene, Mark I.

    AU - Hacking, Ian

    AU - Haurowitz, Felix

    AU - Häyry, Pekka

    AU - Heidelberger, Michael

    AU - Herzenberg, Leonard N.

    AU - Hilschmann, Norbert

    AU - Hoffmann, Geoffrey W.

    AU - Hood, Leroy

    AU - Hübner, Kurt

    AU - Hume, David

    AU - Janeway, Charles A.

    AU - Joao, Cristina

    AU - Jerne, Niels

    AU - Kabat, Elvin A.

    AU - Kazatchkine, Michel D.

    AU - Kitasato, Shibasaburo

    AU - Knorr-Cetina, Karin

    AU - Köhler, Georges J F

    AU - Köhler, Heinz

    AU - Koprowski, Hilary

    AU - Kuhn, Thomas S.

    AU - Kunkel, Henry G.

    AU - Lakatos, Imre

    AU - Landsteiner, Karl

    AU - Latour, Bruno

    AU - Laudan, Larry

    AU - Lederberg, Joshua

    AU - Levy, Ronald

    AU - Mak, Tak W.

    AU - Marrack, Philippa C.

    AU - Marchalonis, John J.

    AU - Matzinger, Polly C E

    AU - McDevitt, Hugh O.

    AU - Medawar, Peter B.

    AU - Miller, Jaques F A

    AU - Milstein, Cesar

    AU - Mitchison, N. Avrion

    AU - Möller, Göran

    AU - Nisonoff, Alfred

    AU - Nossal, Gustav J V

    AU - Ohno, Susumu

    AU - Oudin, Jacques

    AU - Paul, William E.

    AU - Pauling, Linus C.

    AU - Popper, Karl R.

    AU - Porter, Rodney R.

    AU - Potter, Michael

    AU - Quine, Willard V O

    AU - Raff, Martin

    AU - Rajewsky, Klaus

    AU - Reichenbach, Hans

    AU - Rodkey, Scott L.

    AU - Sela, Michael

    AU - Sercarz, Eli E.

    AU - Simonsen, Morton

    AU - Sokal, Alan

    AU - Tada, Tomio

    AU - Talmage, David W.

    AU - Tiselius, Arne W K

    AU - Tonegawa, Susumu

    AU - Uexküll, Thure Von

    AU - Unanue, Emil R.

    AU - Uhr, Jonathan W.

    AU - Urbain, Jacques

    AU - Varela, Francisco J.

    AU - Vaz, Nelson M.

    AU - Watson, James D.

    AU - Wiener, Norbert

    AU - Wigzell, Hans

    AU - Zinkernagel, Rolf M.

    PY - 2008

    Y1 - 2008

    N2 - First-hand account of the rise and fall of a scientific paradigm Shows how scientific fiction turns to fact Highlights the origin of scientific hype Includes interviews with prominent scientists The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual "idiotypic" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the "Eigenbehavior" of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an exciting new perspective of the immune system is now viewed as a scientific vagary, and is largely abandoned. The author, himself a participant in the network vagary, begins with a description of the leading theoretical concepts on fact finding in science. This is followed by a historical account of the rise and fall of the network paradigm, complemented by personal interviews with some of the prominent protagonists. By comparing the network paradigm to other, more lasting concepts in life science, the author develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality.

    AB - First-hand account of the rise and fall of a scientific paradigm Shows how scientific fiction turns to fact Highlights the origin of scientific hype Includes interviews with prominent scientists The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual "idiotypic" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the "Eigenbehavior" of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an exciting new perspective of the immune system is now viewed as a scientific vagary, and is largely abandoned. The author, himself a participant in the network vagary, begins with a description of the leading theoretical concepts on fact finding in science. This is followed by a historical account of the rise and fall of the network paradigm, complemented by personal interviews with some of the prominent protagonists. By comparing the network paradigm to other, more lasting concepts in life science, the author develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality.

    UR - http://www.scopus.com/inward/record.url?scp=84920150948&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84920150948&partnerID=8YFLogxK

    U2 - 10.1007/978-3-7643-8373-2

    DO - 10.1007/978-3-7643-8373-2

    M3 - Book

    SN - 9783764383732

    SN - 9783764383725

    BT - The network collective

    PB - Birkhauser Verlag AG

    ER -