The metabolic syndrome and subclinical carotid atherosclerosis

the Northern Manhattan Study.

Tatjana Rundek, Halina White, Bernadette Boden-Albala, Zhezhen Jin, Mitchell S V Elkind, Ralph L. Sacco

Research output: Contribution to journalArticle

Abstract

The metabolic syndrome (MetS) is a distinctive phenotype associated with an increased risk of vascular disease. Carotid plaque is a surrogate marker of subclinical atherosclerosis and a powerful predictor of vascular outcomes. The relationship between the MetS and subclinical atherosclerosis in multiethnic populations has not been well characterized. The authors have evaluated the association of the MetS with subclinical atherosclerosis among 1895 community residents from the Northern Manhattan Study (mean age, 68.0+/-9.7 years; 59% women; 25% black; 22% white; 51% Hispanic). The prevalence of the MetS was 41% (35% in men, 45% in women), and 57% of subjects had carotid plaque. In a multivariate-adjusted logistic regression model, the MetS was a significant predictor of plaque presence (odds ratio, 1.36; 95% confidence interval, 1.10-1.67). Additionally, the number of MetS components was significantly associated with plaque prevalence. Further studies are needed to understand the role of the MetS in the progression from subclinical to clinical atherosclerotic disease.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalJournal of the CardioMetabolic Syndrome
Volume2
Issue number1
DOIs
StatePublished - Dec 2007

Fingerprint

Carotid Artery Diseases
Atherosclerosis
Logistic Models
Vascular Diseases
Hispanic Americans
Blood Vessels
Biomarkers
Odds Ratio
Confidence Intervals
Phenotype
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The metabolic syndrome and subclinical carotid atherosclerosis : the Northern Manhattan Study. / Rundek, Tatjana; White, Halina; Boden-Albala, Bernadette; Jin, Zhezhen; Elkind, Mitchell S V; Sacco, Ralph L.

In: Journal of the CardioMetabolic Syndrome, Vol. 2, No. 1, 12.2007, p. 24-29.

Research output: Contribution to journalArticle

Rundek, Tatjana ; White, Halina ; Boden-Albala, Bernadette ; Jin, Zhezhen ; Elkind, Mitchell S V ; Sacco, Ralph L. / The metabolic syndrome and subclinical carotid atherosclerosis : the Northern Manhattan Study. In: Journal of the CardioMetabolic Syndrome. 2007 ; Vol. 2, No. 1. pp. 24-29.
@article{132a1605f00a4f2f91b54399b2da78ea,
title = "The metabolic syndrome and subclinical carotid atherosclerosis: the Northern Manhattan Study.",
abstract = "The metabolic syndrome (MetS) is a distinctive phenotype associated with an increased risk of vascular disease. Carotid plaque is a surrogate marker of subclinical atherosclerosis and a powerful predictor of vascular outcomes. The relationship between the MetS and subclinical atherosclerosis in multiethnic populations has not been well characterized. The authors have evaluated the association of the MetS with subclinical atherosclerosis among 1895 community residents from the Northern Manhattan Study (mean age, 68.0+/-9.7 years; 59{\%} women; 25{\%} black; 22{\%} white; 51{\%} Hispanic). The prevalence of the MetS was 41{\%} (35{\%} in men, 45{\%} in women), and 57{\%} of subjects had carotid plaque. In a multivariate-adjusted logistic regression model, the MetS was a significant predictor of plaque presence (odds ratio, 1.36; 95{\%} confidence interval, 1.10-1.67). Additionally, the number of MetS components was significantly associated with plaque prevalence. Further studies are needed to understand the role of the MetS in the progression from subclinical to clinical atherosclerotic disease.",
author = "Tatjana Rundek and Halina White and Bernadette Boden-Albala and Zhezhen Jin and Elkind, {Mitchell S V} and Sacco, {Ralph L.}",
year = "2007",
month = "12",
doi = "10.1111/j.1559-4564.2007.06358.x",
language = "English (US)",
volume = "2",
pages = "24--29",
journal = "Journal of Clinical Hypertension",
issn = "1524-6175",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The metabolic syndrome and subclinical carotid atherosclerosis

T2 - the Northern Manhattan Study.

AU - Rundek, Tatjana

AU - White, Halina

AU - Boden-Albala, Bernadette

AU - Jin, Zhezhen

AU - Elkind, Mitchell S V

AU - Sacco, Ralph L.

PY - 2007/12

Y1 - 2007/12

N2 - The metabolic syndrome (MetS) is a distinctive phenotype associated with an increased risk of vascular disease. Carotid plaque is a surrogate marker of subclinical atherosclerosis and a powerful predictor of vascular outcomes. The relationship between the MetS and subclinical atherosclerosis in multiethnic populations has not been well characterized. The authors have evaluated the association of the MetS with subclinical atherosclerosis among 1895 community residents from the Northern Manhattan Study (mean age, 68.0+/-9.7 years; 59% women; 25% black; 22% white; 51% Hispanic). The prevalence of the MetS was 41% (35% in men, 45% in women), and 57% of subjects had carotid plaque. In a multivariate-adjusted logistic regression model, the MetS was a significant predictor of plaque presence (odds ratio, 1.36; 95% confidence interval, 1.10-1.67). Additionally, the number of MetS components was significantly associated with plaque prevalence. Further studies are needed to understand the role of the MetS in the progression from subclinical to clinical atherosclerotic disease.

AB - The metabolic syndrome (MetS) is a distinctive phenotype associated with an increased risk of vascular disease. Carotid plaque is a surrogate marker of subclinical atherosclerosis and a powerful predictor of vascular outcomes. The relationship between the MetS and subclinical atherosclerosis in multiethnic populations has not been well characterized. The authors have evaluated the association of the MetS with subclinical atherosclerosis among 1895 community residents from the Northern Manhattan Study (mean age, 68.0+/-9.7 years; 59% women; 25% black; 22% white; 51% Hispanic). The prevalence of the MetS was 41% (35% in men, 45% in women), and 57% of subjects had carotid plaque. In a multivariate-adjusted logistic regression model, the MetS was a significant predictor of plaque presence (odds ratio, 1.36; 95% confidence interval, 1.10-1.67). Additionally, the number of MetS components was significantly associated with plaque prevalence. Further studies are needed to understand the role of the MetS in the progression from subclinical to clinical atherosclerotic disease.

UR - http://www.scopus.com/inward/record.url?scp=34548384825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548384825&partnerID=8YFLogxK

U2 - 10.1111/j.1559-4564.2007.06358.x

DO - 10.1111/j.1559-4564.2007.06358.x

M3 - Article

VL - 2

SP - 24

EP - 29

JO - Journal of Clinical Hypertension

JF - Journal of Clinical Hypertension

SN - 1524-6175

IS - 1

ER -