The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum

Daniel E. Neafsey, Kevin Galinsky, Rays H Y Jiang, Lauren Young, Sean M. Sykes, Sakina Saif, Sharvari Gujja, Jonathan M. Goldberg, Sarah Young, Qiandong Zeng, Sinéad B. Chapman, Aditya P. Dash, Anupkumar R. Anvikar, Patrick L. Sutton, Bruce W. Birren, Ananias A. Escalante, John W. Barnwell, Jane M. Carlton

Research output: Contribution to journalArticle

Abstract

We sequenced and annotated the genomes of four P. vivax strains collected from disparate geographic locations, tripling the number of genome sequences available for this understudied parasite and providing the first genome-wide perspective of global variability in this species. We observe approximately twice as much SNP diversity among these isolates as we do among a comparable collection of isolates of P. falciparum, a malaria-causing parasite that results in higher mortality. This indicates a distinct history of global colonization and/or a more stable demographic history for P. vivax relative to P. falciparum, which is thought to have undergone a recent population bottleneck. The SNP diversity, as well as additional microsatellite and gene family variability, suggests a capacity for greater functional variation in the global population of P. vivax. These findings warrant a deeper survey of variation in P. vivax to equip disease interventions targeting the distinctive biology of this neglected but major pathogen.

Original languageEnglish (US)
Pages (from-to)1046-1050
Number of pages5
JournalNature Genetics
Volume44
Issue number9
DOIs
StatePublished - Sep 2012

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Vivax Malaria
Plasmodium vivax
Plasmodium falciparum
Parasites
Genome
Single Nucleotide Polymorphism
Geographic Locations
Falciparum Malaria
Microsatellite Repeats
Population
Demography
Mortality
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Neafsey, D. E., Galinsky, K., Jiang, R. H. Y., Young, L., Sykes, S. M., Saif, S., ... Carlton, J. M. (2012). The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nature Genetics, 44(9), 1046-1050. https://doi.org/10.1038/ng.2373

The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. / Neafsey, Daniel E.; Galinsky, Kevin; Jiang, Rays H Y; Young, Lauren; Sykes, Sean M.; Saif, Sakina; Gujja, Sharvari; Goldberg, Jonathan M.; Young, Sarah; Zeng, Qiandong; Chapman, Sinéad B.; Dash, Aditya P.; Anvikar, Anupkumar R.; Sutton, Patrick L.; Birren, Bruce W.; Escalante, Ananias A.; Barnwell, John W.; Carlton, Jane M.

In: Nature Genetics, Vol. 44, No. 9, 09.2012, p. 1046-1050.

Research output: Contribution to journalArticle

Neafsey, DE, Galinsky, K, Jiang, RHY, Young, L, Sykes, SM, Saif, S, Gujja, S, Goldberg, JM, Young, S, Zeng, Q, Chapman, SB, Dash, AP, Anvikar, AR, Sutton, PL, Birren, BW, Escalante, AA, Barnwell, JW & Carlton, JM 2012, 'The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum', Nature Genetics, vol. 44, no. 9, pp. 1046-1050. https://doi.org/10.1038/ng.2373
Neafsey DE, Galinsky K, Jiang RHY, Young L, Sykes SM, Saif S et al. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nature Genetics. 2012 Sep;44(9):1046-1050. https://doi.org/10.1038/ng.2373
Neafsey, Daniel E. ; Galinsky, Kevin ; Jiang, Rays H Y ; Young, Lauren ; Sykes, Sean M. ; Saif, Sakina ; Gujja, Sharvari ; Goldberg, Jonathan M. ; Young, Sarah ; Zeng, Qiandong ; Chapman, Sinéad B. ; Dash, Aditya P. ; Anvikar, Anupkumar R. ; Sutton, Patrick L. ; Birren, Bruce W. ; Escalante, Ananias A. ; Barnwell, John W. ; Carlton, Jane M. / The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. In: Nature Genetics. 2012 ; Vol. 44, No. 9. pp. 1046-1050.
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