### Abstract

Monazomycin (a positively-charged, polyene-like antibiotic) induces a strongly voltage-dependent conductance in thin lipid membranes when added to one of the bathing solutions. The authors show here that the kinetics of conductance changes after a step of membrane potential are only superficially similar to the kinetics of the potassium gating system of squid giant axons, in that the beginning of conductance increases are growth functions of the time, as opposed to power functions of the time. They find that the rate constant (reciprocal of the time constant) of the growth varies with the approx. 2.6 power of the monazomycin concentration. The rate constant also varies exponentially with membrane potential such that an e-fold change is associated with a 10-11 mV change of membrane potential. They show that solutions of a simple differential equation are able to reproduce the actual conductance changes almost exactly. In the accompanying paper (Muller and Peskin. 1981. J. Gen. Physiol. 78:201-229), the authors derive the differential equation from a molecular model and use the theoretical equation so obtained to investigate the gating current of this system and to predict an interesting form of memory.

Original language | English (US) |
---|---|

Pages (from-to) | 171-200 |

Number of pages | 30 |

Journal | Journal of General Physiology |

Volume | 78 |

Issue number | 2 |

State | Published - 1981 |

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### ASJC Scopus subject areas

- Physiology

### Cite this

*Journal of General Physiology*,

*78*(2), 171-200.

**The kinetics of monazomycin-induced voltage-dependent conductance. I. Proof of the validity of an empirical rate equation.** / Muller, R. U.; Orin, G.; Peskin, Charles.

Research output: Contribution to journal › Article

*Journal of General Physiology*, vol. 78, no. 2, pp. 171-200.

}

TY - JOUR

T1 - The kinetics of monazomycin-induced voltage-dependent conductance. I. Proof of the validity of an empirical rate equation

AU - Muller, R. U.

AU - Orin, G.

AU - Peskin, Charles

PY - 1981

Y1 - 1981

N2 - Monazomycin (a positively-charged, polyene-like antibiotic) induces a strongly voltage-dependent conductance in thin lipid membranes when added to one of the bathing solutions. The authors show here that the kinetics of conductance changes after a step of membrane potential are only superficially similar to the kinetics of the potassium gating system of squid giant axons, in that the beginning of conductance increases are growth functions of the time, as opposed to power functions of the time. They find that the rate constant (reciprocal of the time constant) of the growth varies with the approx. 2.6 power of the monazomycin concentration. The rate constant also varies exponentially with membrane potential such that an e-fold change is associated with a 10-11 mV change of membrane potential. They show that solutions of a simple differential equation are able to reproduce the actual conductance changes almost exactly. In the accompanying paper (Muller and Peskin. 1981. J. Gen. Physiol. 78:201-229), the authors derive the differential equation from a molecular model and use the theoretical equation so obtained to investigate the gating current of this system and to predict an interesting form of memory.

AB - Monazomycin (a positively-charged, polyene-like antibiotic) induces a strongly voltage-dependent conductance in thin lipid membranes when added to one of the bathing solutions. The authors show here that the kinetics of conductance changes after a step of membrane potential are only superficially similar to the kinetics of the potassium gating system of squid giant axons, in that the beginning of conductance increases are growth functions of the time, as opposed to power functions of the time. They find that the rate constant (reciprocal of the time constant) of the growth varies with the approx. 2.6 power of the monazomycin concentration. The rate constant also varies exponentially with membrane potential such that an e-fold change is associated with a 10-11 mV change of membrane potential. They show that solutions of a simple differential equation are able to reproduce the actual conductance changes almost exactly. In the accompanying paper (Muller and Peskin. 1981. J. Gen. Physiol. 78:201-229), the authors derive the differential equation from a molecular model and use the theoretical equation so obtained to investigate the gating current of this system and to predict an interesting form of memory.

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UR - http://www.scopus.com/inward/citedby.url?scp=0019466076&partnerID=8YFLogxK

M3 - Article

C2 - 7276907

AN - SCOPUS:0019466076

VL - 78

SP - 171

EP - 200

JO - Journal of General Physiology

JF - Journal of General Physiology

SN - 0022-1295

IS - 2

ER -