The kinetics of monazomycin-induced voltage-dependent conductance. I. Proof of the validity of an empirical rate equation

R. U. Muller, G. Orin, Charles Peskin

Research output: Contribution to journalArticle

Abstract

Monazomycin (a positively-charged, polyene-like antibiotic) induces a strongly voltage-dependent conductance in thin lipid membranes when added to one of the bathing solutions. The authors show here that the kinetics of conductance changes after a step of membrane potential are only superficially similar to the kinetics of the potassium gating system of squid giant axons, in that the beginning of conductance increases are growth functions of the time, as opposed to power functions of the time. They find that the rate constant (reciprocal of the time constant) of the growth varies with the approx. 2.6 power of the monazomycin concentration. The rate constant also varies exponentially with membrane potential such that an e-fold change is associated with a 10-11 mV change of membrane potential. They show that solutions of a simple differential equation are able to reproduce the actual conductance changes almost exactly. In the accompanying paper (Muller and Peskin. 1981. J. Gen. Physiol. 78:201-229), the authors derive the differential equation from a molecular model and use the theoretical equation so obtained to investigate the gating current of this system and to predict an interesting form of memory.

Original languageEnglish (US)
Pages (from-to)171-200
Number of pages30
JournalJournal of General Physiology
Volume78
Issue number2
StatePublished - 1981

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Membrane Potentials
Polyenes
Decapodiformes
Molecular Models
Membrane Lipids
Growth
Axons
Potassium
Theoretical Models
Anti-Bacterial Agents
monazomycin
Power (Psychology)

ASJC Scopus subject areas

  • Physiology

Cite this

The kinetics of monazomycin-induced voltage-dependent conductance. I. Proof of the validity of an empirical rate equation. / Muller, R. U.; Orin, G.; Peskin, Charles.

In: Journal of General Physiology, Vol. 78, No. 2, 1981, p. 171-200.

Research output: Contribution to journalArticle

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