The in vivo chemistry of photoswitched tethered ligands

Johannes Broichhagen, Dirk Trauner

Research output: Contribution to journalReview article

Abstract

Nature's photoreceptors are typically composed of a chromophore that is covalently bound to a receptor protein at the top of a signaling cascade. The protein can function as a G-protein coupled receptor (GPCR), an ion channel, or as an enzyme. This logic can be mimicked with synthetic photoswitches, such as azobenzenes, that are linked to naturally 'blind' transmembrane proteins using in vivo-chemistry. The resulting semisynthetic receptors can be employed to optically control cellular functions, especially in neurons, and influence the behavior of animals with the exquisite temporal and spatial precision of light.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume21
DOIs
StatePublished - 2014

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Ligands
Animal Behavior
Proteins
Chromophores
G-Protein-Coupled Receptors
Ion Channels
Neurons
Animals
Light
Enzymes
azobenzene

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Medicine(all)

Cite this

The in vivo chemistry of photoswitched tethered ligands. / Broichhagen, Johannes; Trauner, Dirk.

In: Current Opinion in Chemical Biology, Vol. 21, 2014, p. 121-127.

Research output: Contribution to journalReview article

Broichhagen, Johannes ; Trauner, Dirk. / The in vivo chemistry of photoswitched tethered ligands. In: Current Opinion in Chemical Biology. 2014 ; Vol. 21. pp. 121-127.
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