The impact of insecticide-treated school uniforms on dengue infections in school-aged children: Study protocol for a randomised controlled trial in Thailand

Annelies Wilder-Smith, Peter Byass, Phanthip Olanratmanee, Pongsri Maskhao, Luechai Sringernyuang, James G. Logan, Steve W. Lindsay, Sarah Banks, Duane Gubler, Valérie R. Louis, Yesim Tozan, Pattamaporn Kittayapong

Research output: Contribution to journalArticle

Abstract

Background: There is an urgent need to protect children against dengue since this age group is particularly sensitive to the disease. Since dengue vectors are active mainly during the day, a potential target for control should be schools where children spend a considerable amount of their day. School uniforms are the cultural norm in most developing countries, worn throughout the day. We hypothesise that insecticide-treated school uniforms will reduce the incidence of dengue infection in school-aged children. Our objective is to determine the impact of impregnated school uniforms on dengue incidence.Methods: A randomised controlled trial will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-18 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent, high-quality insecticide impregnation with permethrin. A double-blind, randomised, crossover trial at the school level will cover two dengue transmission seasons.Discussion: Practical issues and plans concerning intervention implementation, evaluation, analysing and interpreting the data, and possible policy implications arising from the trial are discussed.Trial registration: clinicaltrial.gov. Registration number: NCT01563640.

Original languageEnglish (US)
Article number212
JournalTrials
Volume13
DOIs
StatePublished - Nov 15 2012

Keywords

  • Cost effectiveness
  • Dengue
  • Insecticide-treated clothes
  • Randomised control trial
  • School children
  • School uniforms

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology (medical)

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    Wilder-Smith, A., Byass, P., Olanratmanee, P., Maskhao, P., Sringernyuang, L., Logan, J. G., Lindsay, S. W., Banks, S., Gubler, D., Louis, V. R., Tozan, Y., & Kittayapong, P. (2012). The impact of insecticide-treated school uniforms on dengue infections in school-aged children: Study protocol for a randomised controlled trial in Thailand. Trials, 13, [212]. https://doi.org/10.1186/1745-6215-13-212