The impact of inflammation on cognitive function in older adults: Implications for healthcare practice and research

Andrea C. Sartori, David E. Vance, Larry Z. Slater, Michael Crowe

Research output: Contribution to journalReview article

Abstract

Accumulating evidence suggests that levels of inflammation, an immune response, increase with age throughout the body and the brain. The effects of inflammation on the brain, both acute and chronic, have been associated with cognitive decline and risk of dementia in older adults. Factors believed to increase inflammation include certain health-related behaviors, such as smoking, poor diet, and inactivity as well as health conditions like diabetes, hypertension, and chronic obstructive pulmonary disease, most of which require medical intervention and monitoring. As such, nurses and healthcare professionals are likely to encounter patients who are at a high risk for future development of inflammation-related cognitive decline. A review of inflammatory processes and their relation to cognitive function in older adults is provided, along with factors that may increase or reduce inflammation. Implications for practice and research are discussed.

Original languageEnglish (US)
Pages (from-to)206-217
Number of pages12
JournalJournal of Neuroscience Nursing
Volume44
Issue number4
DOIs
StatePublished - Aug 1 2012

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ASJC Scopus subject areas

  • Surgery
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Medical–Surgical

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