The human cell atlas

Human Cell Atlas Meeting Participants

Research output: Contribution to journalArticle

Abstract

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Original languageEnglish (US)
Article numbere27041
JournaleLife
Volume6
DOIs
StatePublished - Dec 5 2017

Fingerprint

Atlases
Cells
Gene expression
Trajectories
Throughput
Tissue
Human Body
Transcriptome
Cell Communication

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Human Cell Atlas Meeting Participants (2017). The human cell atlas. eLife, 6, [e27041]. https://doi.org/10.7554/eLife.27041

The human cell atlas. / Human Cell Atlas Meeting Participants.

In: eLife, Vol. 6, e27041, 05.12.2017.

Research output: Contribution to journalArticle

Human Cell Atlas Meeting Participants 2017, 'The human cell atlas', eLife, vol. 6, e27041. https://doi.org/10.7554/eLife.27041
Human Cell Atlas Meeting Participants. The human cell atlas. eLife. 2017 Dec 5;6. e27041. https://doi.org/10.7554/eLife.27041
Human Cell Atlas Meeting Participants. / The human cell atlas. In: eLife. 2017 ; Vol. 6.
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abstract = "The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.",
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