The Gsh2 homeodomain gene controls multiple aspects of telencephalic development

J. G. Corbin, N. Gaiano, R. P. Machold, A. Langston, Gordon Fishell

    Research output: Contribution to journalArticle

    Abstract

    Homeobox genes have recently been demonstrated to be important for the proper patterning of the mammalian telencephalon. One of these genes is Gsh2, whose expression in the forebrain is restricted to the ventral domain. In this study, we demonstrate that Gsh2 is a downstream target of sonic hedgehog and that lack of Gsh2 results in profound defects in telencephalic development. Gsh2 mutants have a significant decrease in the expression of numerous genes that mark early development of the lateral ganglionic eminence, the striatal anlage. Accompanying this early loss of patterning genes is an initial expansion of dorsal telencephalic markers across the cortical-striatal boundary into the lateral ganglionic eminence. Interestingly, as development proceeds, there is compensation for this early loss of markers that is coincident with a molecular reestablishment of the cortical-striatal boundary. Despite this compensation, there is a defect in the development of distinct subpopulations of striatal neurons. Moreover, while our analysis suggests that the migration of the ventrally derived interneurons to the developing cerebral cortex is not significantly affected in Gsh2 mutants, there is a distinct delay in the appearance of GABAergic interneurons in the olfactory bulb. Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development.

    Original languageEnglish (US)
    Pages (from-to)5007-5020
    Number of pages14
    JournalDevelopment
    Volume127
    Issue number23
    StatePublished - Dec 1 2000

    Fingerprint

    Corpus Striatum
    Telencephalon
    Interneurons
    Genes
    Homeobox Genes
    Olfactory Bulb
    Prosencephalon
    Cerebral Cortex
    Gene Expression
    Neurons

    Keywords

    • Gsh2
    • Knockout
    • Mouse
    • Telecephalon

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology

    Cite this

    Corbin, J. G., Gaiano, N., Machold, R. P., Langston, A., & Fishell, G. (2000). The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development, 127(23), 5007-5020.

    The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. / Corbin, J. G.; Gaiano, N.; Machold, R. P.; Langston, A.; Fishell, Gordon.

    In: Development, Vol. 127, No. 23, 01.12.2000, p. 5007-5020.

    Research output: Contribution to journalArticle

    Corbin, JG, Gaiano, N, Machold, RP, Langston, A & Fishell, G 2000, 'The Gsh2 homeodomain gene controls multiple aspects of telencephalic development', Development, vol. 127, no. 23, pp. 5007-5020.
    Corbin JG, Gaiano N, Machold RP, Langston A, Fishell G. The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development. 2000 Dec 1;127(23):5007-5020.
    Corbin, J. G. ; Gaiano, N. ; Machold, R. P. ; Langston, A. ; Fishell, Gordon. / The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. In: Development. 2000 ; Vol. 127, No. 23. pp. 5007-5020.
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