The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors

Tamara Mikeladze-Dvali, Mathias F. Wernet, Daniela Pistillo, Esteban O. Mazzoni, Aurelio A. Teleman, Ya Wen Chen, Stephen Cohen, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Color vision in Drosophila relies on the comparison between two color-sensitive photoreceptors, R7 and R8. Two types of ommatidia in which R7 and R8 contain different rhodopsins are distributed stochastically in the retina and appear to discriminate short (p-subset) or long wavelengths (y-subset). The choice between p and y fates is made in R7, which then instructs R8 to follow the corresponding fate, thus leading to a tight coupling between rhodopsins expressed in R7 and R8. Here, we show that warts, encoding large tumor suppressor (Lats) and melted encoding a PH-domain protein, play opposite roles in defining the yR8 or pR8 fates. By interacting antagonistically at the transcriptional level, they form a bistable loop that insures a robust commitment of R8 to a single fate, without allowing ambiguity. This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted).

Original languageEnglish (US)
Pages (from-to)775-787
Number of pages13
JournalCell
Volume122
Issue number5
DOIs
StatePublished - Sep 9 2005

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Warts
Rhodopsin
Drosophila
Color vision
Color Vision
Cell proliferation
Cell growth
Growth
Retina
Tumors
Color
Genes
Cell Proliferation
Wavelength
Neoplasms
Proteins
Pleckstrin Homology Domains

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. / Mikeladze-Dvali, Tamara; Wernet, Mathias F.; Pistillo, Daniela; Mazzoni, Esteban O.; Teleman, Aurelio A.; Chen, Ya Wen; Cohen, Stephen; Desplan, Claude.

In: Cell, Vol. 122, No. 5, 09.09.2005, p. 775-787.

Research output: Contribution to journalArticle

Mikeladze-Dvali, Tamara ; Wernet, Mathias F. ; Pistillo, Daniela ; Mazzoni, Esteban O. ; Teleman, Aurelio A. ; Chen, Ya Wen ; Cohen, Stephen ; Desplan, Claude. / The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. In: Cell. 2005 ; Vol. 122, No. 5. pp. 775-787.
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AU - Mazzoni, Esteban O.

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