The genome of the sea urchin Strongylocentrotus purpuratus

Erica Sodergren, George M. Weinstock, Eric H. Davidson, R. Andrew Cameron, Richard A. Gibbs, Robert C. Angerer, Lynne M. Angerer, Maria Ina Arnone, David R. Burgess, Robert D. Burke, James A. Coffman, Michael Dean, Maurice R. Elphick, Charles A. Ettensohn, Kathy R. Foltz, Amro Hamdoun, Richard O. Hynes, William H. Klein, William Marzluff, David R. McClayRobert L. Morris, Arcady Mushegian, Jonathan P. Rast, L. Courtney Smith, Michael C. Thorndyke, Victor D. Vacquier, Gary M. Wessel, Greg Wray, Lan Zhang, Christine G. Elsik, Olga Ermolaeva, Wratko Hlavina, Gretchen Hofmann, Paul Kitts, Melissa J. Landrum, Aaron J. Mackey, Donna Maglott, Georgia Panopoulou, Albert J. Poustka, Kim Pruitt, Victor Sapojnikov, Xingzhi Song, Alexandre Souvorov, Victor Solovyev, Zheng Wei, Charles A. Whittaker, Kim Worley, K. James Durbin, Yufeng Shen, Olivier Fedrigo, David Garfield, Ralph Haygood, Alexander Primus, Rahul Satija, Tonya Severson, Manuel L. Gonzalez-Garay, Andrew R. Jackson, Aleksandar Milosavljevic, Mark Tong, Christopher E. Killian, Brian T. Livingston, Fred H. Wilt, Nikki Adams, Robert Bellé, Seth Carbonneau, Rocky Cheung, Patrick Cormier, Bertrand Cosson, Jenifer Croce, Antonio Fernandez-Guerra, Anne Marie Genevière, Manisha Goel, Hemant Kelkar, Julia Morales, Odile Mulner-Lorillon, Anthony J. Robertson, Jared V. Goldstone, Bryan Cole, David Epel, Bert Gold, Mark E. Hahn, Meredith Howard-Ashby, Mark Scally, John J. Stegeman, Erin L. Allgood, Jonah Cool, Kyle M. Judkins, Shawn S. McCafferty, Ashlan M. Musante, Robert A. Obar, Amanda P. Rawson, Blair J. Rossetti, Ian R. Gibbons, Matthew P. Hoffman, Andrew Leone, Sorin Istrail, Stefan C. Materna, Manoj P. Samanta, Viktor Stolc, Waraporn Tongprasit, Qiang Tu, Karl Frederik Bergeron, Bruce P. Brandhorst, James Whittle, Kevin Berney, David J. Bottjer, Cristina Calestani, Kevin Peterson, Elly Chow, Qiu Autumn Yuan, Eran Elhaik, Dan Graur, Justin T. Reese, Ian Bosdet, Shin Heesun, Marco A. Marra, Jacqueline Schein, Michele K. Anderson, Virginia Brockton, Katherine M. Buckley, Avis H. Cohen, Sebastian D. Fugmann, Taku Hibino, Mariano Loza-Coll, Audrey J. Majeske, Cynthia Messier, Sham V. Nair, Zeev Pancer, David P. Terwilliger, Cavit Agca, Enrique Arboleda, Nansheng Chen, Allison M. Churcher, F. Hallböök, Glen W. Humphrey, Mohammed M. Idris, Takae Kiyama, Shuguang Liang, Dan Mellott, Xiuqian Mu, Greg Murray, Robert P. Olinski, Florian Raible, Matthew Rowe, John S. Taylor, Kristin Tessmar-Raible, D. Wang, Karen H. Wilson, Shunsuke Yaguchi, Terry Gaasterland, Blanca E. Galindo, Herath J. Gunaratne, Celina Juliano, Masashi Kinukawa, Gary W. Moy, Anna T. Neill, Mamoru Nomura, Michael Raisch, Anna Reade, Michelle M. Roux, Jia L. Song, Yi Hsien Su, Ian K. Townley, Ekaterina Voronina, Julian L. Wong, Gabriele Amore, Margherita Branno, Euan R. Brown, Vincenzo Cavalieri, Véronique Duboc, Louise Duloquin, Constantin Flytzanis, Christian Gache, François Lapraz, Thierry Lepage, Annamaria Locascio, Pedro Martinez, Giorgio Matassi, Valeria Matranga, Ryan Range, Francesca Rizzo, Eric Röttinger, Karen Wilson, Wendy Beane, Cynthia Bradham, Christine Byrum, Tom Glenn, Sofia Hussain, Mariano Loza, Gerard Manning, Esther Miranda, Rebecca Thomason, Katherine Walton, Athula Wikramanayke, Charles Whittaker, Shu Yu Wu, Ronghui Xu, C. Titus Brown, Lili Chen, Rachel F. Gray, Pei Yun Lee, Jongmin Nam, Paola Oliveri, Joel Smith, Donna Muzny, Stephanie Bell, Joseph Chacko, Andrew Cree, Stacey Curry, Clay Davis, Huyen Dinh, Shannon Dugan-Rocha, Jerry Fowler, Rachel Gill, Cerrissa Hamilton, Judith Hernandez, Sandra Hines, Jennifer Hume, LaRonda Jackson, Angela Jolivet, Christie Kovar, Sandra Lee, Lora Lewis, George Miner, Margaret Morgan, Lynne V. Nazareth, Geoffrey Okwuonu, David Parker, Ling Ling Pu, Rachel Thorn, Rita Wright

Research output: Contribution to journalArticle

Abstract

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

Original languageEnglish (US)
Pages (from-to)941-952
Number of pages12
JournalScience
Volume314
Issue number5801
DOIs
StatePublished - Nov 10 2006

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Strongylocentrotus purpuratus
Sea Urchins
Genome
Bacterial Artificial Chromosomes
Chordata
Developmental Biology
Systems Biology
Firearms
Sequence Analysis
Vertebrates
Clone Cells
Genes

ASJC Scopus subject areas

  • General

Cite this

Sodergren, E., Weinstock, G. M., Davidson, E. H., Cameron, R. A., Gibbs, R. A., Angerer, R. C., ... Wright, R. (2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science, 314(5801), 941-952. https://doi.org/10.1126/science.1133609

The genome of the sea urchin Strongylocentrotus purpuratus. / Sodergren, Erica; Weinstock, George M.; Davidson, Eric H.; Cameron, R. Andrew; Gibbs, Richard A.; Angerer, Robert C.; Angerer, Lynne M.; Arnone, Maria Ina; Burgess, David R.; Burke, Robert D.; Coffman, James A.; Dean, Michael; Elphick, Maurice R.; Ettensohn, Charles A.; Foltz, Kathy R.; Hamdoun, Amro; Hynes, Richard O.; Klein, William H.; Marzluff, William; McClay, David R.; Morris, Robert L.; Mushegian, Arcady; Rast, Jonathan P.; Smith, L. Courtney; Thorndyke, Michael C.; Vacquier, Victor D.; Wessel, Gary M.; Wray, Greg; Zhang, Lan; Elsik, Christine G.; Ermolaeva, Olga; Hlavina, Wratko; Hofmann, Gretchen; Kitts, Paul; Landrum, Melissa J.; Mackey, Aaron J.; Maglott, Donna; Panopoulou, Georgia; Poustka, Albert J.; Pruitt, Kim; Sapojnikov, Victor; Song, Xingzhi; Souvorov, Alexandre; Solovyev, Victor; Wei, Zheng; Whittaker, Charles A.; Worley, Kim; Durbin, K. James; Shen, Yufeng; Fedrigo, Olivier; Garfield, David; Haygood, Ralph; Primus, Alexander; Satija, Rahul; Severson, Tonya; Gonzalez-Garay, Manuel L.; Jackson, Andrew R.; Milosavljevic, Aleksandar; Tong, Mark; Killian, Christopher E.; Livingston, Brian T.; Wilt, Fred H.; Adams, Nikki; Bellé, Robert; Carbonneau, Seth; Cheung, Rocky; Cormier, Patrick; Cosson, Bertrand; Croce, Jenifer; Fernandez-Guerra, Antonio; Genevière, Anne Marie; Goel, Manisha; Kelkar, Hemant; Morales, Julia; Mulner-Lorillon, Odile; Robertson, Anthony J.; Goldstone, Jared V.; Cole, Bryan; Epel, David; Gold, Bert; Hahn, Mark E.; Howard-Ashby, Meredith; Scally, Mark; Stegeman, John J.; Allgood, Erin L.; Cool, Jonah; Judkins, Kyle M.; McCafferty, Shawn S.; Musante, Ashlan M.; Obar, Robert A.; Rawson, Amanda P.; Rossetti, Blair J.; Gibbons, Ian R.; Hoffman, Matthew P.; Leone, Andrew; Istrail, Sorin; Materna, Stefan C.; Samanta, Manoj P.; Stolc, Viktor; Tongprasit, Waraporn; Tu, Qiang; Bergeron, Karl Frederik; Brandhorst, Bruce P.; Whittle, James; Berney, Kevin; Bottjer, David J.; Calestani, Cristina; Peterson, Kevin; Chow, Elly; Yuan, Qiu Autumn; Elhaik, Eran; Graur, Dan; Reese, Justin T.; Bosdet, Ian; Heesun, Shin; Marra, Marco A.; Schein, Jacqueline; Anderson, Michele K.; Brockton, Virginia; Buckley, Katherine M.; Cohen, Avis H.; Fugmann, Sebastian D.; Hibino, Taku; Loza-Coll, Mariano; Majeske, Audrey J.; Messier, Cynthia; Nair, Sham V.; Pancer, Zeev; Terwilliger, David P.; Agca, Cavit; Arboleda, Enrique; Chen, Nansheng; Churcher, Allison M.; Hallböök, F.; Humphrey, Glen W.; Idris, Mohammed M.; Kiyama, Takae; Liang, Shuguang; Mellott, Dan; Mu, Xiuqian; Murray, Greg; Olinski, Robert P.; Raible, Florian; Rowe, Matthew; Taylor, John S.; Tessmar-Raible, Kristin; Wang, D.; Wilson, Karen H.; Yaguchi, Shunsuke; Gaasterland, Terry; Galindo, Blanca E.; Gunaratne, Herath J.; Juliano, Celina; Kinukawa, Masashi; Moy, Gary W.; Neill, Anna T.; Nomura, Mamoru; Raisch, Michael; Reade, Anna; Roux, Michelle M.; Song, Jia L.; Su, Yi Hsien; Townley, Ian K.; Voronina, Ekaterina; Wong, Julian L.; Amore, Gabriele; Branno, Margherita; Brown, Euan R.; Cavalieri, Vincenzo; Duboc, Véronique; Duloquin, Louise; Flytzanis, Constantin; Gache, Christian; Lapraz, François; Lepage, Thierry; Locascio, Annamaria; Martinez, Pedro; Matassi, Giorgio; Matranga, Valeria; Range, Ryan; Rizzo, Francesca; Röttinger, Eric; Wilson, Karen; Beane, Wendy; Bradham, Cynthia; Byrum, Christine; Glenn, Tom; Hussain, Sofia; Loza, Mariano; Manning, Gerard; Miranda, Esther; Thomason, Rebecca; Walton, Katherine; Wikramanayke, Athula; Whittaker, Charles; Wu, Shu Yu; Xu, Ronghui; Brown, C. Titus; Chen, Lili; Gray, Rachel F.; Lee, Pei Yun; Nam, Jongmin; Oliveri, Paola; Smith, Joel; Muzny, Donna; Bell, Stephanie; Chacko, Joseph; Cree, Andrew; Curry, Stacey; Davis, Clay; Dinh, Huyen; Dugan-Rocha, Shannon; Fowler, Jerry; Gill, Rachel; Hamilton, Cerrissa; Hernandez, Judith; Hines, Sandra; Hume, Jennifer; Jackson, LaRonda; Jolivet, Angela; Kovar, Christie; Lee, Sandra; Lewis, Lora; Miner, George; Morgan, Margaret; Nazareth, Lynne V.; Okwuonu, Geoffrey; Parker, David; Pu, Ling Ling; Thorn, Rachel; Wright, Rita.

In: Science, Vol. 314, No. 5801, 10.11.2006, p. 941-952.

Research output: Contribution to journalArticle

Sodergren, E, Weinstock, GM, Davidson, EH, Cameron, RA, Gibbs, RA, Angerer, RC, Angerer, LM, Arnone, MI, Burgess, DR, Burke, RD, Coffman, JA, Dean, M, Elphick, MR, Ettensohn, CA, Foltz, KR, Hamdoun, A, Hynes, RO, Klein, WH, Marzluff, W, McClay, DR, Morris, RL, Mushegian, A, Rast, JP, Smith, LC, Thorndyke, MC, Vacquier, VD, Wessel, GM, Wray, G, Zhang, L, Elsik, CG, Ermolaeva, O, Hlavina, W, Hofmann, G, Kitts, P, Landrum, MJ, Mackey, AJ, Maglott, D, Panopoulou, G, Poustka, AJ, Pruitt, K, Sapojnikov, V, Song, X, Souvorov, A, Solovyev, V, Wei, Z, Whittaker, CA, Worley, K, Durbin, KJ, Shen, Y, Fedrigo, O, Garfield, D, Haygood, R, Primus, A, Satija, R, Severson, T, Gonzalez-Garay, ML, Jackson, AR, Milosavljevic, A, Tong, M, Killian, CE, Livingston, BT, Wilt, FH, Adams, N, Bellé, R, Carbonneau, S, Cheung, R, Cormier, P, Cosson, B, Croce, J, Fernandez-Guerra, A, Genevière, AM, Goel, M, Kelkar, H, Morales, J, Mulner-Lorillon, O, Robertson, AJ, Goldstone, JV, Cole, B, Epel, D, Gold, B, Hahn, ME, Howard-Ashby, M, Scally, M, Stegeman, JJ, Allgood, EL, Cool, J, Judkins, KM, McCafferty, SS, Musante, AM, Obar, RA, Rawson, AP, Rossetti, BJ, Gibbons, IR, Hoffman, MP, Leone, A, Istrail, S, Materna, SC, Samanta, MP, Stolc, V, Tongprasit, W, Tu, Q, Bergeron, KF, Brandhorst, BP, Whittle, J, Berney, K, Bottjer, DJ, Calestani, C, Peterson, K, Chow, E, Yuan, QA, Elhaik, E, Graur, D, Reese, JT, Bosdet, I, Heesun, S, Marra, MA, Schein, J, Anderson, MK, Brockton, V, Buckley, KM, Cohen, AH, Fugmann, SD, Hibino, T, Loza-Coll, M, Majeske, AJ, Messier, C, Nair, SV, Pancer, Z, Terwilliger, DP, Agca, C, Arboleda, E, Chen, N, Churcher, AM, Hallböök, F, Humphrey, GW, Idris, MM, Kiyama, T, Liang, S, Mellott, D, Mu, X, Murray, G, Olinski, RP, Raible, F, Rowe, M, Taylor, JS, Tessmar-Raible, K, Wang, D, Wilson, KH, Yaguchi, S, Gaasterland, T, Galindo, BE, Gunaratne, HJ, Juliano, C, Kinukawa, M, Moy, GW, Neill, AT, Nomura, M, Raisch, M, Reade, A, Roux, MM, Song, JL, Su, YH, Townley, IK, Voronina, E, Wong, JL, Amore, G, Branno, M, Brown, ER, Cavalieri, V, Duboc, V, Duloquin, L, Flytzanis, C, Gache, C, Lapraz, F, Lepage, T, Locascio, A, Martinez, P, Matassi, G, Matranga, V, Range, R, Rizzo, F, Röttinger, E, Wilson, K, Beane, W, Bradham, C, Byrum, C, Glenn, T, Hussain, S, Loza, M, Manning, G, Miranda, E, Thomason, R, Walton, K, Wikramanayke, A, Whittaker, C, Wu, SY, Xu, R, Brown, CT, Chen, L, Gray, RF, Lee, PY, Nam, J, Oliveri, P, Smith, J, Muzny, D, Bell, S, Chacko, J, Cree, A, Curry, S, Davis, C, Dinh, H, Dugan-Rocha, S, Fowler, J, Gill, R, Hamilton, C, Hernandez, J, Hines, S, Hume, J, Jackson, L, Jolivet, A, Kovar, C, Lee, S, Lewis, L, Miner, G, Morgan, M, Nazareth, LV, Okwuonu, G, Parker, D, Pu, LL, Thorn, R & Wright, R 2006, 'The genome of the sea urchin Strongylocentrotus purpuratus', Science, vol. 314, no. 5801, pp. 941-952. https://doi.org/10.1126/science.1133609
Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10;314(5801):941-952. https://doi.org/10.1126/science.1133609
Sodergren, Erica ; Weinstock, George M. ; Davidson, Eric H. ; Cameron, R. Andrew ; Gibbs, Richard A. ; Angerer, Robert C. ; Angerer, Lynne M. ; Arnone, Maria Ina ; Burgess, David R. ; Burke, Robert D. ; Coffman, James A. ; Dean, Michael ; Elphick, Maurice R. ; Ettensohn, Charles A. ; Foltz, Kathy R. ; Hamdoun, Amro ; Hynes, Richard O. ; Klein, William H. ; Marzluff, William ; McClay, David R. ; Morris, Robert L. ; Mushegian, Arcady ; Rast, Jonathan P. ; Smith, L. Courtney ; Thorndyke, Michael C. ; Vacquier, Victor D. ; Wessel, Gary M. ; Wray, Greg ; Zhang, Lan ; Elsik, Christine G. ; Ermolaeva, Olga ; Hlavina, Wratko ; Hofmann, Gretchen ; Kitts, Paul ; Landrum, Melissa J. ; Mackey, Aaron J. ; Maglott, Donna ; Panopoulou, Georgia ; Poustka, Albert J. ; Pruitt, Kim ; Sapojnikov, Victor ; Song, Xingzhi ; Souvorov, Alexandre ; Solovyev, Victor ; Wei, Zheng ; Whittaker, Charles A. ; Worley, Kim ; Durbin, K. James ; Shen, Yufeng ; Fedrigo, Olivier ; Garfield, David ; Haygood, Ralph ; Primus, Alexander ; Satija, Rahul ; Severson, Tonya ; Gonzalez-Garay, Manuel L. ; Jackson, Andrew R. ; Milosavljevic, Aleksandar ; Tong, Mark ; Killian, Christopher E. ; Livingston, Brian T. ; Wilt, Fred H. ; Adams, Nikki ; Bellé, Robert ; Carbonneau, Seth ; Cheung, Rocky ; Cormier, Patrick ; Cosson, Bertrand ; Croce, Jenifer ; Fernandez-Guerra, Antonio ; Genevière, Anne Marie ; Goel, Manisha ; Kelkar, Hemant ; Morales, Julia ; Mulner-Lorillon, Odile ; Robertson, Anthony J. ; Goldstone, Jared V. ; Cole, Bryan ; Epel, David ; Gold, Bert ; Hahn, Mark E. ; Howard-Ashby, Meredith ; Scally, Mark ; Stegeman, John J. ; Allgood, Erin L. ; Cool, Jonah ; Judkins, Kyle M. ; McCafferty, Shawn S. ; Musante, Ashlan M. ; Obar, Robert A. ; Rawson, Amanda P. ; Rossetti, Blair J. ; Gibbons, Ian R. ; Hoffman, Matthew P. ; Leone, Andrew ; Istrail, Sorin ; Materna, Stefan C. ; Samanta, Manoj P. ; Stolc, Viktor ; Tongprasit, Waraporn ; Tu, Qiang ; Bergeron, Karl Frederik ; Brandhorst, Bruce P. ; Whittle, James ; Berney, Kevin ; Bottjer, David J. ; Calestani, Cristina ; Peterson, Kevin ; Chow, Elly ; Yuan, Qiu Autumn ; Elhaik, Eran ; Graur, Dan ; Reese, Justin T. ; Bosdet, Ian ; Heesun, Shin ; Marra, Marco A. ; Schein, Jacqueline ; Anderson, Michele K. ; Brockton, Virginia ; Buckley, Katherine M. ; Cohen, Avis H. ; Fugmann, Sebastian D. ; Hibino, Taku ; Loza-Coll, Mariano ; Majeske, Audrey J. ; Messier, Cynthia ; Nair, Sham V. ; Pancer, Zeev ; Terwilliger, David P. ; Agca, Cavit ; Arboleda, Enrique ; Chen, Nansheng ; Churcher, Allison M. ; Hallböök, F. ; Humphrey, Glen W. ; Idris, Mohammed M. ; Kiyama, Takae ; Liang, Shuguang ; Mellott, Dan ; Mu, Xiuqian ; Murray, Greg ; Olinski, Robert P. ; Raible, Florian ; Rowe, Matthew ; Taylor, John S. ; Tessmar-Raible, Kristin ; Wang, D. ; Wilson, Karen H. ; Yaguchi, Shunsuke ; Gaasterland, Terry ; Galindo, Blanca E. ; Gunaratne, Herath J. ; Juliano, Celina ; Kinukawa, Masashi ; Moy, Gary W. ; Neill, Anna T. ; Nomura, Mamoru ; Raisch, Michael ; Reade, Anna ; Roux, Michelle M. ; Song, Jia L. ; Su, Yi Hsien ; Townley, Ian K. ; Voronina, Ekaterina ; Wong, Julian L. ; Amore, Gabriele ; Branno, Margherita ; Brown, Euan R. ; Cavalieri, Vincenzo ; Duboc, Véronique ; Duloquin, Louise ; Flytzanis, Constantin ; Gache, Christian ; Lapraz, François ; Lepage, Thierry ; Locascio, Annamaria ; Martinez, Pedro ; Matassi, Giorgio ; Matranga, Valeria ; Range, Ryan ; Rizzo, Francesca ; Röttinger, Eric ; Wilson, Karen ; Beane, Wendy ; Bradham, Cynthia ; Byrum, Christine ; Glenn, Tom ; Hussain, Sofia ; Loza, Mariano ; Manning, Gerard ; Miranda, Esther ; Thomason, Rebecca ; Walton, Katherine ; Wikramanayke, Athula ; Whittaker, Charles ; Wu, Shu Yu ; Xu, Ronghui ; Brown, C. Titus ; Chen, Lili ; Gray, Rachel F. ; Lee, Pei Yun ; Nam, Jongmin ; Oliveri, Paola ; Smith, Joel ; Muzny, Donna ; Bell, Stephanie ; Chacko, Joseph ; Cree, Andrew ; Curry, Stacey ; Davis, Clay ; Dinh, Huyen ; Dugan-Rocha, Shannon ; Fowler, Jerry ; Gill, Rachel ; Hamilton, Cerrissa ; Hernandez, Judith ; Hines, Sandra ; Hume, Jennifer ; Jackson, LaRonda ; Jolivet, Angela ; Kovar, Christie ; Lee, Sandra ; Lewis, Lora ; Miner, George ; Morgan, Margaret ; Nazareth, Lynne V. ; Okwuonu, Geoffrey ; Parker, David ; Pu, Ling Ling ; Thorn, Rachel ; Wright, Rita. / The genome of the sea urchin Strongylocentrotus purpuratus. In: Science. 2006 ; Vol. 314, No. 5801. pp. 941-952.
@article{0525a2f0bfc144418fc2d5ba29eff57d,
title = "The genome of the sea urchin Strongylocentrotus purpuratus",
abstract = "We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.",
author = "Erica Sodergren and Weinstock, {George M.} and Davidson, {Eric H.} and Cameron, {R. Andrew} and Gibbs, {Richard A.} and Angerer, {Robert C.} and Angerer, {Lynne M.} and Arnone, {Maria Ina} and Burgess, {David R.} and Burke, {Robert D.} and Coffman, {James A.} and Michael Dean and Elphick, {Maurice R.} and Ettensohn, {Charles A.} and Foltz, {Kathy R.} and Amro Hamdoun and Hynes, {Richard O.} and Klein, {William H.} and William Marzluff and McClay, {David R.} and Morris, {Robert L.} and Arcady Mushegian and Rast, {Jonathan P.} and Smith, {L. Courtney} and Thorndyke, {Michael C.} and Vacquier, {Victor D.} and Wessel, {Gary M.} and Greg Wray and Lan Zhang and Elsik, {Christine G.} and Olga Ermolaeva and Wratko Hlavina and Gretchen Hofmann and Paul Kitts and Landrum, {Melissa J.} and Mackey, {Aaron J.} and Donna Maglott and Georgia Panopoulou and Poustka, {Albert J.} and Kim Pruitt and Victor Sapojnikov and Xingzhi Song and Alexandre Souvorov and Victor Solovyev and Zheng Wei and Whittaker, {Charles A.} and Kim Worley and Durbin, {K. James} and Yufeng Shen and Olivier Fedrigo and David Garfield and Ralph Haygood and Alexander Primus and Rahul Satija and Tonya Severson and Gonzalez-Garay, {Manuel L.} and Jackson, {Andrew R.} and Aleksandar Milosavljevic and Mark Tong and Killian, {Christopher E.} and Livingston, {Brian T.} and Wilt, {Fred H.} and Nikki Adams and Robert Bell{\'e} and Seth Carbonneau and Rocky Cheung and Patrick Cormier and Bertrand Cosson and Jenifer Croce and Antonio Fernandez-Guerra and Genevi{\`e}re, {Anne Marie} and Manisha Goel and Hemant Kelkar and Julia Morales and Odile Mulner-Lorillon and Robertson, {Anthony J.} and Goldstone, {Jared V.} and Bryan Cole and David Epel and Bert Gold and Hahn, {Mark E.} and Meredith Howard-Ashby and Mark Scally and Stegeman, {John J.} and Allgood, {Erin L.} and Jonah Cool and Judkins, {Kyle M.} and McCafferty, {Shawn S.} and Musante, {Ashlan M.} and Obar, {Robert A.} and Rawson, {Amanda P.} and Rossetti, {Blair J.} and Gibbons, {Ian R.} and Hoffman, {Matthew P.} and Andrew Leone and Sorin Istrail and Materna, {Stefan C.} and Samanta, {Manoj P.} and Viktor Stolc and Waraporn Tongprasit and Qiang Tu and Bergeron, {Karl Frederik} and Brandhorst, {Bruce P.} and James Whittle and Kevin Berney and Bottjer, {David J.} and Cristina Calestani and Kevin Peterson and Elly Chow and Yuan, {Qiu Autumn} and Eran Elhaik and Dan Graur and Reese, {Justin T.} and Ian Bosdet and Shin Heesun and Marra, {Marco A.} and Jacqueline Schein and Anderson, {Michele K.} and Virginia Brockton and Buckley, {Katherine M.} and Cohen, {Avis H.} and Fugmann, {Sebastian D.} and Taku Hibino and Mariano Loza-Coll and Majeske, {Audrey J.} and Cynthia Messier and Nair, {Sham V.} and Zeev Pancer and Terwilliger, {David P.} and Cavit Agca and Enrique Arboleda and Nansheng Chen and Churcher, {Allison M.} and F. Hallb{\"o}{\"o}k and Humphrey, {Glen W.} and Idris, {Mohammed M.} and Takae Kiyama and Shuguang Liang and Dan Mellott and Xiuqian Mu and Greg Murray and Olinski, {Robert P.} and Florian Raible and Matthew Rowe and Taylor, {John S.} and Kristin Tessmar-Raible and D. Wang and Wilson, {Karen H.} and Shunsuke Yaguchi and Terry Gaasterland and Galindo, {Blanca E.} and Gunaratne, {Herath J.} and Celina Juliano and Masashi Kinukawa and Moy, {Gary W.} and Neill, {Anna T.} and Mamoru Nomura and Michael Raisch and Anna Reade and Roux, {Michelle M.} and Song, {Jia L.} and Su, {Yi Hsien} and Townley, {Ian K.} and Ekaterina Voronina and Wong, {Julian L.} and Gabriele Amore and Margherita Branno and Brown, {Euan R.} and Vincenzo Cavalieri and V{\'e}ronique Duboc and Louise Duloquin and Constantin Flytzanis and Christian Gache and Fran{\cc}ois Lapraz and Thierry Lepage and Annamaria Locascio and Pedro Martinez and Giorgio Matassi and Valeria Matranga and Ryan Range and Francesca Rizzo and Eric R{\"o}ttinger and Karen Wilson and Wendy Beane and Cynthia Bradham and Christine Byrum and Tom Glenn and Sofia Hussain and Mariano Loza and Gerard Manning and Esther Miranda and Rebecca Thomason and Katherine Walton and Athula Wikramanayke and Charles Whittaker and Wu, {Shu Yu} and Ronghui Xu and Brown, {C. Titus} and Lili Chen and Gray, {Rachel F.} and Lee, {Pei Yun} and Jongmin Nam and Paola Oliveri and Joel Smith and Donna Muzny and Stephanie Bell and Joseph Chacko and Andrew Cree and Stacey Curry and Clay Davis and Huyen Dinh and Shannon Dugan-Rocha and Jerry Fowler and Rachel Gill and Cerrissa Hamilton and Judith Hernandez and Sandra Hines and Jennifer Hume and LaRonda Jackson and Angela Jolivet and Christie Kovar and Sandra Lee and Lora Lewis and George Miner and Margaret Morgan and Nazareth, {Lynne V.} and Geoffrey Okwuonu and David Parker and Pu, {Ling Ling} and Rachel Thorn and Rita Wright",
year = "2006",
month = "11",
day = "10",
doi = "10.1126/science.1133609",
language = "English (US)",
volume = "314",
pages = "941--952",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5801",

}

TY - JOUR

T1 - The genome of the sea urchin Strongylocentrotus purpuratus

AU - Sodergren, Erica

AU - Weinstock, George M.

AU - Davidson, Eric H.

AU - Cameron, R. Andrew

AU - Gibbs, Richard A.

AU - Angerer, Robert C.

AU - Angerer, Lynne M.

AU - Arnone, Maria Ina

AU - Burgess, David R.

AU - Burke, Robert D.

AU - Coffman, James A.

AU - Dean, Michael

AU - Elphick, Maurice R.

AU - Ettensohn, Charles A.

AU - Foltz, Kathy R.

AU - Hamdoun, Amro

AU - Hynes, Richard O.

AU - Klein, William H.

AU - Marzluff, William

AU - McClay, David R.

AU - Morris, Robert L.

AU - Mushegian, Arcady

AU - Rast, Jonathan P.

AU - Smith, L. Courtney

AU - Thorndyke, Michael C.

AU - Vacquier, Victor D.

AU - Wessel, Gary M.

AU - Wray, Greg

AU - Zhang, Lan

AU - Elsik, Christine G.

AU - Ermolaeva, Olga

AU - Hlavina, Wratko

AU - Hofmann, Gretchen

AU - Kitts, Paul

AU - Landrum, Melissa J.

AU - Mackey, Aaron J.

AU - Maglott, Donna

AU - Panopoulou, Georgia

AU - Poustka, Albert J.

AU - Pruitt, Kim

AU - Sapojnikov, Victor

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PY - 2006/11/10

Y1 - 2006/11/10

N2 - We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

AB - We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

UR - http://www.scopus.com/inward/record.url?scp=33750995860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750995860&partnerID=8YFLogxK

U2 - 10.1126/science.1133609

DO - 10.1126/science.1133609

M3 - Article

VL - 314

SP - 941

EP - 952

JO - Science

JF - Science

SN - 0036-8075

IS - 5801

ER -