The genome of the blood fluke Schistosoma mansoni

Matthew Berriman, Brian J. Haas, Philip T. Loverde, R. Alan Wilson, Gary P. Dillon, Gustavo C. Cerqueira, Susan T. Mashiyama, Bissan Al-Lazikani, Luiza F. Andrade, Peter D. Ashton, Martin A. Aslett, Daniella C. Bartholomeu, Gaelle Blandin, Conor R. Caffrey, Avril Coghlan, Richard Coulson, Tim A. Day, Art Delcher, Ricardo Demarco, Appolinaire DjikengTina Eyre, John A. Gamble, Elodie Ghedin, Yong Gu, Christiane Hertz-Fowler, Hirohisha Hirai, Yuriko Hirai, Robin Houston, Alasdair Ivens, David A. Johnston, Daniela Lacerda, Camila D. MacEdo, Paul McVeigh, Zemin Ning, Guilherme Oliveira, John P. Overington, Julian Parkhill, Mihaela Pertea, Raymond J. Pierce, Anna V. Protasio, Michael A. Quail, Marie Adèle Rajandream, Jane Rogers, Mohammed Sajid, Steven L. Salzberg, Mario Stanke, Adrian R. Tivey, Owen White, David L. Williams, Jennifer Wortman, Wenjie Wu, Mostafa Zamanian, Adhemar Zerlotini, Claire M. Fraser-Liggett, Barclay G. Barrell, Najib M. El-Sayed

Research output: Contribution to journalArticle

Abstract

Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the identification of membrane receptors, ion channels and more than 300 proteases provide new insights into the biology of the life cycle and new targets. Bioinformatics approaches have identified metabolic chokepoints, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease.

Original languageEnglish (US)
Pages (from-to)352-358
Number of pages7
JournalNature
Volume460
Issue number7253
DOIs
StatePublished - Jul 16 2009

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Neglected Diseases
Trematoda
Schistosoma mansoni
Platyhelminths
Genome
Schistosomiasis
Alternative Splicing
Life Cycle Stages
Computational Biology
Ion Channels
Lipid Metabolism
Pharmaceutical Preparations
Introns
Genes
Exons
Peptide Hydrolases
Membranes
Research
Proteins

ASJC Scopus subject areas

  • General

Cite this

Berriman, M., Haas, B. J., Loverde, P. T., Wilson, R. A., Dillon, G. P., Cerqueira, G. C., ... El-Sayed, N. M. (2009). The genome of the blood fluke Schistosoma mansoni. Nature, 460(7253), 352-358. https://doi.org/10.1038/nature08160

The genome of the blood fluke Schistosoma mansoni. / Berriman, Matthew; Haas, Brian J.; Loverde, Philip T.; Wilson, R. Alan; Dillon, Gary P.; Cerqueira, Gustavo C.; Mashiyama, Susan T.; Al-Lazikani, Bissan; Andrade, Luiza F.; Ashton, Peter D.; Aslett, Martin A.; Bartholomeu, Daniella C.; Blandin, Gaelle; Caffrey, Conor R.; Coghlan, Avril; Coulson, Richard; Day, Tim A.; Delcher, Art; Demarco, Ricardo; Djikeng, Appolinaire; Eyre, Tina; Gamble, John A.; Ghedin, Elodie; Gu, Yong; Hertz-Fowler, Christiane; Hirai, Hirohisha; Hirai, Yuriko; Houston, Robin; Ivens, Alasdair; Johnston, David A.; Lacerda, Daniela; MacEdo, Camila D.; McVeigh, Paul; Ning, Zemin; Oliveira, Guilherme; Overington, John P.; Parkhill, Julian; Pertea, Mihaela; Pierce, Raymond J.; Protasio, Anna V.; Quail, Michael A.; Rajandream, Marie Adèle; Rogers, Jane; Sajid, Mohammed; Salzberg, Steven L.; Stanke, Mario; Tivey, Adrian R.; White, Owen; Williams, David L.; Wortman, Jennifer; Wu, Wenjie; Zamanian, Mostafa; Zerlotini, Adhemar; Fraser-Liggett, Claire M.; Barrell, Barclay G.; El-Sayed, Najib M.

In: Nature, Vol. 460, No. 7253, 16.07.2009, p. 352-358.

Research output: Contribution to journalArticle

Berriman, M, Haas, BJ, Loverde, PT, Wilson, RA, Dillon, GP, Cerqueira, GC, Mashiyama, ST, Al-Lazikani, B, Andrade, LF, Ashton, PD, Aslett, MA, Bartholomeu, DC, Blandin, G, Caffrey, CR, Coghlan, A, Coulson, R, Day, TA, Delcher, A, Demarco, R, Djikeng, A, Eyre, T, Gamble, JA, Ghedin, E, Gu, Y, Hertz-Fowler, C, Hirai, H, Hirai, Y, Houston, R, Ivens, A, Johnston, DA, Lacerda, D, MacEdo, CD, McVeigh, P, Ning, Z, Oliveira, G, Overington, JP, Parkhill, J, Pertea, M, Pierce, RJ, Protasio, AV, Quail, MA, Rajandream, MA, Rogers, J, Sajid, M, Salzberg, SL, Stanke, M, Tivey, AR, White, O, Williams, DL, Wortman, J, Wu, W, Zamanian, M, Zerlotini, A, Fraser-Liggett, CM, Barrell, BG & El-Sayed, NM 2009, 'The genome of the blood fluke Schistosoma mansoni', Nature, vol. 460, no. 7253, pp. 352-358. https://doi.org/10.1038/nature08160
Berriman M, Haas BJ, Loverde PT, Wilson RA, Dillon GP, Cerqueira GC et al. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16;460(7253):352-358. https://doi.org/10.1038/nature08160
Berriman, Matthew ; Haas, Brian J. ; Loverde, Philip T. ; Wilson, R. Alan ; Dillon, Gary P. ; Cerqueira, Gustavo C. ; Mashiyama, Susan T. ; Al-Lazikani, Bissan ; Andrade, Luiza F. ; Ashton, Peter D. ; Aslett, Martin A. ; Bartholomeu, Daniella C. ; Blandin, Gaelle ; Caffrey, Conor R. ; Coghlan, Avril ; Coulson, Richard ; Day, Tim A. ; Delcher, Art ; Demarco, Ricardo ; Djikeng, Appolinaire ; Eyre, Tina ; Gamble, John A. ; Ghedin, Elodie ; Gu, Yong ; Hertz-Fowler, Christiane ; Hirai, Hirohisha ; Hirai, Yuriko ; Houston, Robin ; Ivens, Alasdair ; Johnston, David A. ; Lacerda, Daniela ; MacEdo, Camila D. ; McVeigh, Paul ; Ning, Zemin ; Oliveira, Guilherme ; Overington, John P. ; Parkhill, Julian ; Pertea, Mihaela ; Pierce, Raymond J. ; Protasio, Anna V. ; Quail, Michael A. ; Rajandream, Marie Adèle ; Rogers, Jane ; Sajid, Mohammed ; Salzberg, Steven L. ; Stanke, Mario ; Tivey, Adrian R. ; White, Owen ; Williams, David L. ; Wortman, Jennifer ; Wu, Wenjie ; Zamanian, Mostafa ; Zerlotini, Adhemar ; Fraser-Liggett, Claire M. ; Barrell, Barclay G. ; El-Sayed, Najib M. / The genome of the blood fluke Schistosoma mansoni. In: Nature. 2009 ; Vol. 460, No. 7253. pp. 352-358.
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