The evolution of the Conserved ATPase Domain (CAD)

Reconstructing the history of an ancient protein module

Jonathan C. Swaffield, Michael D. Purugganan

Research output: Contribution to journalArticle

Abstract

The AAA proteins (ATPases Associated with a variety of cellular Activities) are found in eubacterial, archaebacterial, and eukaryotic species and participate in a large number of cellular processes, including protein degradation, vesicle fusion, cell cycle control, and cellular secretory processes. The AAA proteins are characterized by the presence of a 230 to 250-amino acid ATPase domain referred to as the Conserved ATPase Domain or CAD. Phylogenetic analysis of 133 CAD sequences from 38 species reveal that AAA CADs are organized into discrete groups that are related not only in structure but in cellular function. Evolutionary analyses also indicate that the CAD was present in the last common ancestor of eubacteria, archaebacteria, and eukaryotes. The eubacterial CADs are found in metalloproteases, while CAD-containing proteins in the amhaebacterial and eukaryotic lineages appear to have diversified by a series of gene duplication events that lead to the establishment of different functional AAA proteins, including proteasomal regulatory, NSF/Sec, and Pas proteins. The phylogeny of the CADs provides the basis for establishing the patterns of evolutionary change that characterize the AAA proteins.

Original languageEnglish (US)
Pages (from-to)549-563
Number of pages15
JournalJournal of Molecular Evolution
Volume45
Issue number5
DOIs
StatePublished - 1997

Fingerprint

Ancient History
adenosinetriphosphatase
Adenosine Triphosphatases
history
protein
computer aided design
Proteins
proteins
Computer aided design
Eubacteria
Gene Duplication
Secretory Pathway
cell structures
Archaea
phylogeny
Metalloproteases
metalloproteinases
common ancestry
eukaryote
gene duplication

Keywords

  • AAA proteins
  • ATPase
  • Metalloprotease
  • NSF
  • Pas
  • Proteasome
  • Sec

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)

Cite this

The evolution of the Conserved ATPase Domain (CAD) : Reconstructing the history of an ancient protein module. / Swaffield, Jonathan C.; Purugganan, Michael D.

In: Journal of Molecular Evolution, Vol. 45, No. 5, 1997, p. 549-563.

Research output: Contribution to journalArticle

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