The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate)

Molecular details of action

Pance Naumov, Nobuhiro Yasuda, Wael Rabeh, Joel Bernstein

Research output: Contribution to journalArticle

Abstract

The first structure determination of a neuraminidase inhibitor, oseltamivir phosphate, the active component of the anti-influenza agent Tamiflu, was achieved by single crystal X-ray diffraction with synchrotron radiation. The structure reproduces to a great extent the binding of the inhibitor in the neuraminidase active site and provides more accurate structural parameters as well as detailed insight into the binding preferences of the inhibitor.

Original languageEnglish (US)
Pages (from-to)1948-1950
Number of pages3
JournalChemical Communications
Volume49
Issue number19
DOIs
StatePublished - Mar 7 2013

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Oseltamivir
Neuraminidase
Synchrotron radiation
Phosphates
Crystal structure
Single crystals
X ray diffraction

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate) : Molecular details of action. / Naumov, Pance; Yasuda, Nobuhiro; Rabeh, Wael; Bernstein, Joel.

In: Chemical Communications, Vol. 49, No. 19, 07.03.2013, p. 1948-1950.

Research output: Contribution to journalArticle

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