The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

Richard Vogel, I. B. Lamster, S. A. Wechsler, B. Macedo, L. J. Hartley, J. A. Macedo

Research output: Contribution to journalArticle

Abstract

A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalJournal of Periodontology
Volume57
Issue number8
StatePublished - Aug 1986

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Gingivitis
Chemotaxis
Ascorbic Acid
Neutrophils
Recommended Dietary Allowances
Double-Blind Method
Vitamins
Placebos

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Vogel, R., Lamster, I. B., Wechsler, S. A., Macedo, B., Hartley, L. J., & Macedo, J. A. (1986). The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. Journal of Periodontology, 57(8), 472-479.

The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. / Vogel, Richard; Lamster, I. B.; Wechsler, S. A.; Macedo, B.; Hartley, L. J.; Macedo, J. A.

In: Journal of Periodontology, Vol. 57, No. 8, 08.1986, p. 472-479.

Research output: Contribution to journalArticle

Vogel, R, Lamster, IB, Wechsler, SA, Macedo, B, Hartley, LJ & Macedo, JA 1986, 'The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.', Journal of Periodontology, vol. 57, no. 8, pp. 472-479.
Vogel R, Lamster IB, Wechsler SA, Macedo B, Hartley LJ, Macedo JA. The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. Journal of Periodontology. 1986 Aug;57(8):472-479.
Vogel, Richard ; Lamster, I. B. ; Wechsler, S. A. ; Macedo, B. ; Hartley, L. J. ; Macedo, J. A. / The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. In: Journal of Periodontology. 1986 ; Vol. 57, No. 8. pp. 472-479.
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