The effects of dietary protein and amino acids on skeletal metabolism

Jessica Bihuniak, Karl L. Insogna

Research output: Contribution to journalArticle

Abstract

Dietary protein is required for optimal skeletal growth and maturation. Although Recommended Dietary Allowances (RDAs) exist for global dietary protein intake, the level and sources of dietary protein that are optimal for skeletal health over the life continuum have not been established. This is partly due to the difficulty in quantifying the effects of variable levels of a nutrient's intake over a lifetime as well as the complex nature of the relationships between dietary protein and calcium economy. Areas of current uncertainty include the precise source and amount of dietary protein required for optimal skeletal accretion and maintenance of skeletal mass, as well as the site-specific effects of dietary protein. The cellular and molecular mechanisms that underpin the actions of dietary protein on mineral metabolism and skeletal homeostasis remain unclear. This review attempts to summarize recent data bearing on these questions.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume410
DOIs
StatePublished - Jul 5 2015

Fingerprint

Dietary Proteins
Metabolism
Amino Acids
Bearings (structural)
Dietary Calcium
Recommended Dietary Allowances
Nutrients
Uncertainty
Minerals
Homeostasis
Maintenance
Health
Food
Growth

Keywords

  • Amino acids
  • Calcium absorption
  • Dietary protein
  • IGF-1
  • Skeletal health

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

The effects of dietary protein and amino acids on skeletal metabolism. / Bihuniak, Jessica; Insogna, Karl L.

In: Molecular and Cellular Endocrinology, Vol. 410, 05.07.2015, p. 78-86.

Research output: Contribution to journalArticle

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