The effect of HAART on salivary microbiota in the Women's Interagency HIV Study (WIHS)

Mavash Navazesh, Roseann Mulligan, Janice Pogoda, Deborah Greenspan, Mario Alves, Joan Phelan, John Greenspan, Jorgen Slots

Research output: Contribution to journalArticle

Abstract

Objective. Study the prevalence of potentially pathogenic microorganisms in saliva of HIV-positive women in the Women's Interagency HIV Study. Study design. 157 HIV-positive and 31 HIV-negative women were studied. At baseline and every 6 months over 4 years, information was collected on socioeconomic and educational status, oral and systemic health, including HIV markers and antiretroviral therapy, and frequency of professional oral care utilization. Bacterial and yeast pathogenic isolates from stimulated whole saliva were tentatively identified using standard methodologies. Results. The prevalence of microorganisms in stimulated saliva of HIV-positive women was not significantly different from that of HIV-negative women. In HIV-positive women, highly active antiretroviral therapy (HAART) was independently and significantly associated with the presence of a variety of salivary bacterial species. HAART increased the risk for recovering Fusobacterium species (P < .001), enteric gram-negative rods (P < .05), Peptostreptococcus micros (P < .05), Campylobacter species (P < .0001), Eubacterium species (P < .001), and Tannerella forsythia (P < .01). In contrast, HAART led to decreased recovery rate of yeasts (Candida albicans and Candida dubliniensis) (P < .0001). Conclusion. The present findings suggest that the institution of HAART promotes an increasingly pathogenic salivary microbiota, at least temporarily. Similar findings have been reported for various nonoral microbial ecosystems.

Original languageEnglish (US)
Pages (from-to)701-708
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume100
Issue number6
DOIs
StatePublished - Dec 2005

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Microbiota
Highly Active Antiretroviral Therapy
HIV
Saliva
Eubacterium
Yeasts
Fusobacterium
Peptostreptococcus
Educational Status
Campylobacter
Oral Health
Candida albicans
Candida
Social Class
Ecosystem
Cross-Sectional Studies

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

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The effect of HAART on salivary microbiota in the Women's Interagency HIV Study (WIHS). / Navazesh, Mavash; Mulligan, Roseann; Pogoda, Janice; Greenspan, Deborah; Alves, Mario; Phelan, Joan; Greenspan, John; Slots, Jorgen.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 100, No. 6, 12.2005, p. 701-708.

Research output: Contribution to journalArticle

Navazesh, M, Mulligan, R, Pogoda, J, Greenspan, D, Alves, M, Phelan, J, Greenspan, J & Slots, J 2005, 'The effect of HAART on salivary microbiota in the Women's Interagency HIV Study (WIHS)', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 100, no. 6, pp. 701-708. https://doi.org/10.1016/j.tripleo.2004.10.011
Navazesh, Mavash ; Mulligan, Roseann ; Pogoda, Janice ; Greenspan, Deborah ; Alves, Mario ; Phelan, Joan ; Greenspan, John ; Slots, Jorgen. / The effect of HAART on salivary microbiota in the Women's Interagency HIV Study (WIHS). In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2005 ; Vol. 100, No. 6. pp. 701-708.
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