The effect of brain-derived neurotrophic factor on periodontal furcation defects

Ryo Jimbo, Nick Tovar, Malvin N. Janal, Ramy Mousa, Charles Marin, Daniel Yoo, Hellen S. Teixeira, Rodolfo B. Anchieta, Estevam A. Bonfante, Akihiro Konishi, Katsuhiro Takeda, Hidemi Kurihara, Paulo Coelho

Research output: Contribution to journalArticle

Abstract

This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 μg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 μg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 μg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.

Original languageEnglish (US)
Article numbere84845
JournalPLoS One
Volume9
Issue number1
DOIs
StatePublished - Jan 14 2014

Fingerprint

Furcation Defects
neurotrophins
Brain-Derived Neurotrophic Factor
hyaluronic acid
Hyaluronic Acid
brain
Defects
Bone
Molecular Weight
Molecular weight
bones
molecular weight
Primates
Zygoma
Dental Cementum
micro-computed tomography
Bone and Bones
Periodontal Ligament
Ligaments
ligaments

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The effect of brain-derived neurotrophic factor on periodontal furcation defects. / Jimbo, Ryo; Tovar, Nick; Janal, Malvin N.; Mousa, Ramy; Marin, Charles; Yoo, Daniel; Teixeira, Hellen S.; Anchieta, Rodolfo B.; Bonfante, Estevam A.; Konishi, Akihiro; Takeda, Katsuhiro; Kurihara, Hidemi; Coelho, Paulo.

In: PLoS One, Vol. 9, No. 1, e84845, 14.01.2014.

Research output: Contribution to journalArticle

Jimbo, R, Tovar, N, Janal, MN, Mousa, R, Marin, C, Yoo, D, Teixeira, HS, Anchieta, RB, Bonfante, EA, Konishi, A, Takeda, K, Kurihara, H & Coelho, P 2014, 'The effect of brain-derived neurotrophic factor on periodontal furcation defects', PLoS One, vol. 9, no. 1, e84845. https://doi.org/10.1371/journal.pone.0084845
Jimbo R, Tovar N, Janal MN, Mousa R, Marin C, Yoo D et al. The effect of brain-derived neurotrophic factor on periodontal furcation defects. PLoS One. 2014 Jan 14;9(1). e84845. https://doi.org/10.1371/journal.pone.0084845
Jimbo, Ryo ; Tovar, Nick ; Janal, Malvin N. ; Mousa, Ramy ; Marin, Charles ; Yoo, Daniel ; Teixeira, Hellen S. ; Anchieta, Rodolfo B. ; Bonfante, Estevam A. ; Konishi, Akihiro ; Takeda, Katsuhiro ; Kurihara, Hidemi ; Coelho, Paulo. / The effect of brain-derived neurotrophic factor on periodontal furcation defects. In: PLoS One. 2014 ; Vol. 9, No. 1.
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