The effect of ammonium glycopyrrolate (Robinul®)-induced xerostomia on oral mucosal wetness and flow of gingival crevicular fluid in humans

Mark Wolff, I. Kleinberg

Research output: Contribution to journalArticle

Abstract

The antisialogogue, ammonium glycopyrrolate (Robinul®), was used to reduce the salivary flow rate in healthy individuals with normal salivary function to determine whether the dry-mouth symptoms and reduced amounts and patterns of oral mucosal wetness found previously in hyposalivators could be induced by this means. After baseline measurements, the drug was given to 10 healthy volunteers and their resting whole-saliva flow rate was measured at 0, 15, 60, 105 and 150 min thereafter. At the same times, the thickness of the layer of residual mucosal saliva (a measure of residual mucosal wetness) at each of 22 intraoral sites was also determined. The saliva flow rate fell from a mean of 0.45 ± 0.07 ml/min to a mean of 0.05+ 0.02 ml/mm by 1 h and slowly thereafter to a mean of 0.02 ± 0.01 to 0.03 ± 0.01 ml/min for the remainder of the experiment. Onset of dryness symptoms was observed approx. 30 min after giving the drug. Simultaneously, the residual saliva at each of the 22 sites teted decreased to a thickness level previously found in patients with hyposalivation and who exhibited an intense feeling of dry mouth. Despite these decreases in thickness, the pattern of residual mucosal wetness throughout the mouth remained more or less unchanged. As in earlier studies, wetness was least on the hard palate and highest on the posterior dorsum of the tongue. An altered taste of the residual saliva in the mouth and an increased feeling of roughness as the tongue was passed over labial and buccal mucosal surfaces were noted. The amount of gingival crevicular fluid (GCF) in 12 gingival sites in each of the participants was also measured. Unlike the reduction in salivary flow, changes in GCF over the 150 min of the study were negligible. From this it was concluded that GCF could contribute much more to the oral fluids in dry-mouth than in normal individuals, especially when there is greater gingival inflammation.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalArchives of Oral Biology
Volume44
Issue number2
DOIs
StatePublished - Feb 1999

Fingerprint

Glycopyrrolate
Gingival Crevicular Fluid
Xerostomia
Ammonium Compounds
Saliva
Mouth
Tongue
Emotions
Dysgeusia
Hard Palate
Cheek
Lip
Pharmaceutical Preparations
Healthy Volunteers
Inflammation

Keywords

  • Ammonium glycopyrrolate (Robinul®)
  • Dry mouth
  • Mucosal wetness
  • Residual saliva
  • Saliva films

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

@article{e81fe29318b44dd7a5d0cd474e9c45c2,
title = "The effect of ammonium glycopyrrolate (Robinul{\circledR})-induced xerostomia on oral mucosal wetness and flow of gingival crevicular fluid in humans",
abstract = "The antisialogogue, ammonium glycopyrrolate (Robinul{\circledR}), was used to reduce the salivary flow rate in healthy individuals with normal salivary function to determine whether the dry-mouth symptoms and reduced amounts and patterns of oral mucosal wetness found previously in hyposalivators could be induced by this means. After baseline measurements, the drug was given to 10 healthy volunteers and their resting whole-saliva flow rate was measured at 0, 15, 60, 105 and 150 min thereafter. At the same times, the thickness of the layer of residual mucosal saliva (a measure of residual mucosal wetness) at each of 22 intraoral sites was also determined. The saliva flow rate fell from a mean of 0.45 ± 0.07 ml/min to a mean of 0.05+ 0.02 ml/mm by 1 h and slowly thereafter to a mean of 0.02 ± 0.01 to 0.03 ± 0.01 ml/min for the remainder of the experiment. Onset of dryness symptoms was observed approx. 30 min after giving the drug. Simultaneously, the residual saliva at each of the 22 sites teted decreased to a thickness level previously found in patients with hyposalivation and who exhibited an intense feeling of dry mouth. Despite these decreases in thickness, the pattern of residual mucosal wetness throughout the mouth remained more or less unchanged. As in earlier studies, wetness was least on the hard palate and highest on the posterior dorsum of the tongue. An altered taste of the residual saliva in the mouth and an increased feeling of roughness as the tongue was passed over labial and buccal mucosal surfaces were noted. The amount of gingival crevicular fluid (GCF) in 12 gingival sites in each of the participants was also measured. Unlike the reduction in salivary flow, changes in GCF over the 150 min of the study were negligible. From this it was concluded that GCF could contribute much more to the oral fluids in dry-mouth than in normal individuals, especially when there is greater gingival inflammation.",
keywords = "Ammonium glycopyrrolate (Robinul{\circledR}), Dry mouth, Mucosal wetness, Residual saliva, Saliva films",
author = "Mark Wolff and I. Kleinberg",
year = "1999",
month = "2",
doi = "10.1016/S0003-9969(98)00113-7",
language = "English (US)",
volume = "44",
pages = "97--102",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - The effect of ammonium glycopyrrolate (Robinul®)-induced xerostomia on oral mucosal wetness and flow of gingival crevicular fluid in humans

AU - Wolff, Mark

AU - Kleinberg, I.

PY - 1999/2

Y1 - 1999/2

N2 - The antisialogogue, ammonium glycopyrrolate (Robinul®), was used to reduce the salivary flow rate in healthy individuals with normal salivary function to determine whether the dry-mouth symptoms and reduced amounts and patterns of oral mucosal wetness found previously in hyposalivators could be induced by this means. After baseline measurements, the drug was given to 10 healthy volunteers and their resting whole-saliva flow rate was measured at 0, 15, 60, 105 and 150 min thereafter. At the same times, the thickness of the layer of residual mucosal saliva (a measure of residual mucosal wetness) at each of 22 intraoral sites was also determined. The saliva flow rate fell from a mean of 0.45 ± 0.07 ml/min to a mean of 0.05+ 0.02 ml/mm by 1 h and slowly thereafter to a mean of 0.02 ± 0.01 to 0.03 ± 0.01 ml/min for the remainder of the experiment. Onset of dryness symptoms was observed approx. 30 min after giving the drug. Simultaneously, the residual saliva at each of the 22 sites teted decreased to a thickness level previously found in patients with hyposalivation and who exhibited an intense feeling of dry mouth. Despite these decreases in thickness, the pattern of residual mucosal wetness throughout the mouth remained more or less unchanged. As in earlier studies, wetness was least on the hard palate and highest on the posterior dorsum of the tongue. An altered taste of the residual saliva in the mouth and an increased feeling of roughness as the tongue was passed over labial and buccal mucosal surfaces were noted. The amount of gingival crevicular fluid (GCF) in 12 gingival sites in each of the participants was also measured. Unlike the reduction in salivary flow, changes in GCF over the 150 min of the study were negligible. From this it was concluded that GCF could contribute much more to the oral fluids in dry-mouth than in normal individuals, especially when there is greater gingival inflammation.

AB - The antisialogogue, ammonium glycopyrrolate (Robinul®), was used to reduce the salivary flow rate in healthy individuals with normal salivary function to determine whether the dry-mouth symptoms and reduced amounts and patterns of oral mucosal wetness found previously in hyposalivators could be induced by this means. After baseline measurements, the drug was given to 10 healthy volunteers and their resting whole-saliva flow rate was measured at 0, 15, 60, 105 and 150 min thereafter. At the same times, the thickness of the layer of residual mucosal saliva (a measure of residual mucosal wetness) at each of 22 intraoral sites was also determined. The saliva flow rate fell from a mean of 0.45 ± 0.07 ml/min to a mean of 0.05+ 0.02 ml/mm by 1 h and slowly thereafter to a mean of 0.02 ± 0.01 to 0.03 ± 0.01 ml/min for the remainder of the experiment. Onset of dryness symptoms was observed approx. 30 min after giving the drug. Simultaneously, the residual saliva at each of the 22 sites teted decreased to a thickness level previously found in patients with hyposalivation and who exhibited an intense feeling of dry mouth. Despite these decreases in thickness, the pattern of residual mucosal wetness throughout the mouth remained more or less unchanged. As in earlier studies, wetness was least on the hard palate and highest on the posterior dorsum of the tongue. An altered taste of the residual saliva in the mouth and an increased feeling of roughness as the tongue was passed over labial and buccal mucosal surfaces were noted. The amount of gingival crevicular fluid (GCF) in 12 gingival sites in each of the participants was also measured. Unlike the reduction in salivary flow, changes in GCF over the 150 min of the study were negligible. From this it was concluded that GCF could contribute much more to the oral fluids in dry-mouth than in normal individuals, especially when there is greater gingival inflammation.

KW - Ammonium glycopyrrolate (Robinul®)

KW - Dry mouth

KW - Mucosal wetness

KW - Residual saliva

KW - Saliva films

UR - http://www.scopus.com/inward/record.url?scp=0033082254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033082254&partnerID=8YFLogxK

U2 - 10.1016/S0003-9969(98)00113-7

DO - 10.1016/S0003-9969(98)00113-7

M3 - Article

VL - 44

SP - 97

EP - 102

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 2

ER -