The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

Christine Rushlow, A. Hogan, S. M. Pinchin, K. M. Howe, M. Lardelli, D. Ish-Horowicz

Research output: Contribution to journalArticle

Abstract

The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.

Original languageEnglish (US)
Pages (from-to)3095-3103
Number of pages9
JournalEMBO Journal
Volume8
Issue number10
StatePublished - Oct 1989

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Genes
Protein Multimerization
Proteins
myc Genes
Dimerization
DNA sequences
DNA-Binding Proteins
Drosophila
Complementary DNA
Amino Acids
DNA
Drosophila hairy protein

ASJC Scopus subject areas

  • Cell Biology

Cite this

Rushlow, C., Hogan, A., Pinchin, S. M., Howe, K. M., Lardelli, M., & Ish-Horowicz, D. (1989). The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. EMBO Journal, 8(10), 3095-3103.

The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. / Rushlow, Christine; Hogan, A.; Pinchin, S. M.; Howe, K. M.; Lardelli, M.; Ish-Horowicz, D.

In: EMBO Journal, Vol. 8, No. 10, 10.1989, p. 3095-3103.

Research output: Contribution to journalArticle

Rushlow, C, Hogan, A, Pinchin, SM, Howe, KM, Lardelli, M & Ish-Horowicz, D 1989, 'The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.', EMBO Journal, vol. 8, no. 10, pp. 3095-3103.
Rushlow C, Hogan A, Pinchin SM, Howe KM, Lardelli M, Ish-Horowicz D. The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. EMBO Journal. 1989 Oct;8(10):3095-3103.
Rushlow, Christine ; Hogan, A. ; Pinchin, S. M. ; Howe, K. M. ; Lardelli, M. ; Ish-Horowicz, D. / The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. In: EMBO Journal. 1989 ; Vol. 8, No. 10. pp. 3095-3103.
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