The DRD4 VNTR polymorphism influences reactivity to smoking cues

Kent E. Hutchison, Heather LaChance, Raymond Niaura, Angela Bryan, Andrew Smolen

Research output: Contribution to journalArticle

Abstract

Recent research has indicated that craving for tobacco can be reliably elicited by exposure to smoking cues, suggesting that cue-elicited craving for tobacco may be a useful phenotype for research on genetic factors related to nicotine dependence. Given the potential role of dopamine in cue-elicited craving, the authors examined whether the DRD4 VNTR polymorphism is associated with cue-elicited craving for tobacco. Participants who were homozygous or heterozygous for the 7 repeat (or longer) allele were classified as DRD4 L, and all other participants were classified as DRD4 S. Participants were exposed to smoking cues before smoking either high-nicotine cigarettes or control cigarettes. Analyses suggested that participants in the L group demonstrated significantly greater craving, more arousal, less positive affect, and more attention to the smoking cues than did the participants in the S group.

Original languageEnglish (US)
Pages (from-to)134-143
Number of pages10
JournalJournal of Abnormal Psychology
Volume111
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Cues
Smoking
Tobacco
Tobacco Products
Tobacco Use Disorder
Genetic Research
Arousal
Nicotine
Polymorphism
Reactivity
Dopamine
Alleles
Craving
Phenotype
Research

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)

Cite this

The DRD4 VNTR polymorphism influences reactivity to smoking cues. / Hutchison, Kent E.; LaChance, Heather; Niaura, Raymond; Bryan, Angela; Smolen, Andrew.

In: Journal of Abnormal Psychology, Vol. 111, No. 1, 2002, p. 134-143.

Research output: Contribution to journalArticle

Hutchison, Kent E. ; LaChance, Heather ; Niaura, Raymond ; Bryan, Angela ; Smolen, Andrew. / The DRD4 VNTR polymorphism influences reactivity to smoking cues. In: Journal of Abnormal Psychology. 2002 ; Vol. 111, No. 1. pp. 134-143.
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