The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy

Jerome Percus, Ora E. Percus, Martin Markowitz, David D. Ho, Michele Di Mascio, Alan S. Perelson

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus type 1 (HIV-1) infected patients treated with combination antiretroviral therapy frequently have the level of HIV-1 RNA detectable in plasma driven below the lower limit of detection of current assays, 50 copies ml-1. Patients may continue to exhibit viral loads (VLs) below the assay limit for years, yet on some occasions the VL may be above the limit of detection. Whether these 'blips' in VL are simply assay errors or are indicative of intermittent episodes of increased viral replication is of great clinical concern. By analyzing the occurrence of viral blips in 123 treated HIV-infected patients, we show that patients do not share a common probability distribution of blip amplitude and thus reject the hypothesis that blips are solely due to assay variation.

Original languageEnglish (US)
Pages (from-to)263-277
Number of pages15
JournalBulletin of Mathematical Biology
Volume65
Issue number2
DOIs
StatePublished - Mar 2003

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human immunodeficiency virus
Human immunodeficiency virus 1
Viruses
Virus
Therapy
HIV-1
Assays
viral load
Viral Load
assay
therapeutics
assays
Limit of Detection
detection limit
Replication
probability distribution
Probability Distribution
Continue
Therapeutics
Plasma

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy. / Percus, Jerome; Percus, Ora E.; Markowitz, Martin; Ho, David D.; Di Mascio, Michele; Perelson, Alan S.

In: Bulletin of Mathematical Biology, Vol. 65, No. 2, 03.2003, p. 263-277.

Research output: Contribution to journalArticle

Percus, Jerome ; Percus, Ora E. ; Markowitz, Martin ; Ho, David D. ; Di Mascio, Michele ; Perelson, Alan S. / The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy. In: Bulletin of Mathematical Biology. 2003 ; Vol. 65, No. 2. pp. 263-277.
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