The Chemical Biology of DNA Damage

Research output: Book/ReportBook

Abstract

Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.

Original languageEnglish (US)
PublisherWiley-VCH
Number of pages449
ISBN (Print)9783527322954
DOIs
StatePublished - Oct 11 2010

Fingerprint

DNA Damage
DNA
DNA Replication
DNA Repair
Toxicology
Transcription
Health
Repair

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The Chemical Biology of DNA Damage. / Geacintov, Nicholas E.; Broyde, Suse.

Wiley-VCH, 2010. 449 p.

Research output: Book/ReportBook

@book{965a0074c1d94cfc8638864f3a01465d,
title = "The Chemical Biology of DNA Damage",
abstract = "Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.",
author = "Geacintov, {Nicholas E.} and Suse Broyde",
year = "2010",
month = "10",
day = "11",
doi = "10.1002/9783527630110",
language = "English (US)",
isbn = "9783527322954",
publisher = "Wiley-VCH",

}

TY - BOOK

T1 - The Chemical Biology of DNA Damage

AU - Geacintov, Nicholas E.

AU - Broyde, Suse

PY - 2010/10/11

Y1 - 2010/10/11

N2 - Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.

AB - Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.

UR - http://www.scopus.com/inward/record.url?scp=77957580394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957580394&partnerID=8YFLogxK

U2 - 10.1002/9783527630110

DO - 10.1002/9783527630110

M3 - Book

AN - SCOPUS:77957580394

SN - 9783527322954

BT - The Chemical Biology of DNA Damage

PB - Wiley-VCH

ER -