The BC200 RNA gene and its neural expression are conserved in Anthropoidea (Primates)

Boris V. Skryabin, Joachim Kremerskothen, Dido Vassilacopoulou, Todd Disotell, Vladimir V. Kapitonov, Jerzy Jurka, Jürgen Brosius

    Research output: Contribution to journalArticle

    Abstract

    The gene encoding BC200 RNA arose from a monomeric Alu element. Subsequently, the RNA had been recruited or exapted into a function of the nervous system. Here we confirm the presence of the BC200 gene in several primate species among the Anthropoidea. The period following the divergence of New World monkeys and Old World monkeys from their common ancestor is characterized by a significantly higher substitution rate in the examined 5' flanking region than in the BC200 RNA coding region itself. Furthermore, the conservation of CpG dimers in the RNA coding region (200 bp) is drastically increased compared to the 5' flanking region (~400 bp) over all 12 species examined. Finally, the brain-specific expression pattern of BC200 RNA and its presence as a ribonucleoprotein particle (RNP) are conserved in Old World and New World monkeys. Our studies indicate that the gene encoding BC200 RNA was created at least 35-55 million years ago and its presence, mode of expression, and association with protein(s) as an RNP are under selective pressure.

    Original languageEnglish (US)
    Pages (from-to)677-685
    Number of pages9
    JournalJournal of Molecular Evolution
    Volume47
    Issue number6
    DOIs
    StatePublished - 1998

    Fingerprint

    primate
    Primates
    Haplorhini
    RNA
    Genes
    gene
    Platyrrhini
    ribonucleoproteins
    Cebidae
    Gene encoding
    Ribonucleoproteins
    genes
    5' Flanking Region
    Alu Elements
    Cercopithecidae
    Neurology
    common ancestry
    nervous system
    Dimers
    Nervous System

    Keywords

    • Anthropoidea
    • BC200 small cytoplasmic RNA
    • Exaptation
    • Monomeric Alu repetitive element
    • Neural expression
    • Primates
    • Ribonucleoprotein complex (RNP)

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Agricultural and Biological Sciences (miscellaneous)
    • Ecology, Evolution, Behavior and Systematics
    • Biochemistry, Genetics and Molecular Biology(all)
    • Biochemistry
    • Genetics
    • Molecular Biology
    • Genetics(clinical)

    Cite this

    Skryabin, B. V., Kremerskothen, J., Vassilacopoulou, D., Disotell, T., Kapitonov, V. V., Jurka, J., & Brosius, J. (1998). The BC200 RNA gene and its neural expression are conserved in Anthropoidea (Primates). Journal of Molecular Evolution, 47(6), 677-685. https://doi.org/10.1007/PL00006426

    The BC200 RNA gene and its neural expression are conserved in Anthropoidea (Primates). / Skryabin, Boris V.; Kremerskothen, Joachim; Vassilacopoulou, Dido; Disotell, Todd; Kapitonov, Vladimir V.; Jurka, Jerzy; Brosius, Jürgen.

    In: Journal of Molecular Evolution, Vol. 47, No. 6, 1998, p. 677-685.

    Research output: Contribution to journalArticle

    Skryabin, BV, Kremerskothen, J, Vassilacopoulou, D, Disotell, T, Kapitonov, VV, Jurka, J & Brosius, J 1998, 'The BC200 RNA gene and its neural expression are conserved in Anthropoidea (Primates)', Journal of Molecular Evolution, vol. 47, no. 6, pp. 677-685. https://doi.org/10.1007/PL00006426
    Skryabin BV, Kremerskothen J, Vassilacopoulou D, Disotell T, Kapitonov VV, Jurka J et al. The BC200 RNA gene and its neural expression are conserved in Anthropoidea (Primates). Journal of Molecular Evolution. 1998;47(6):677-685. https://doi.org/10.1007/PL00006426
    Skryabin, Boris V. ; Kremerskothen, Joachim ; Vassilacopoulou, Dido ; Disotell, Todd ; Kapitonov, Vladimir V. ; Jurka, Jerzy ; Brosius, Jürgen. / The BC200 RNA gene and its neural expression are conserved in Anthropoidea (Primates). In: Journal of Molecular Evolution. 1998 ; Vol. 47, No. 6. pp. 677-685.
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