The asynchronous state in cortical circuits

Alfonso Renart, Jaime De La Rocha, Peter Bartho, Liad Hollender, Néstor Parga, Alexander Reyes, Kenneth D. Harris

Research output: Contribution to journalArticle

Abstract

Correlated spiking is often observed in cortical drcuits, but its functional role is controversial. It is believed that correlations are a consequence of shared inputs between nearby neurons and could severely constrain information decoding. Here we show theoretically that recurrent neural networks can generate an asynchronous state characterized by arbitrarily low mean spiking correlations despite substantial amounts of shared input. In this state, spontaneous fluctuations in the activity of excitatory and inhibitory populations accurately track each other, generating negative correlations in synaptic currents which cancel the effect of shared input. Near-zero mean correlations were seen experimentally in recordings from rodent neocortex in vivo. Our results suggest a reexamination of the sources underlying observed correlations and their functional consequences for information processing.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalScience
Volume327
Issue number5965
DOIs
StatePublished - 2010

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Neocortex
Automatic Data Processing
Rodentia
Neurons
Population

ASJC Scopus subject areas

  • General

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Renart, A., De La Rocha, J., Bartho, P., Hollender, L., Parga, N., Reyes, A., & Harris, K. D. (2010). The asynchronous state in cortical circuits. Science, 327(5965), 587-590. https://doi.org/10.1126/science.1179850

The asynchronous state in cortical circuits. / Renart, Alfonso; De La Rocha, Jaime; Bartho, Peter; Hollender, Liad; Parga, Néstor; Reyes, Alexander; Harris, Kenneth D.

In: Science, Vol. 327, No. 5965, 2010, p. 587-590.

Research output: Contribution to journalArticle

Renart, A, De La Rocha, J, Bartho, P, Hollender, L, Parga, N, Reyes, A & Harris, KD 2010, 'The asynchronous state in cortical circuits', Science, vol. 327, no. 5965, pp. 587-590. https://doi.org/10.1126/science.1179850
Renart A, De La Rocha J, Bartho P, Hollender L, Parga N, Reyes A et al. The asynchronous state in cortical circuits. Science. 2010;327(5965):587-590. https://doi.org/10.1126/science.1179850
Renart, Alfonso ; De La Rocha, Jaime ; Bartho, Peter ; Hollender, Liad ; Parga, Néstor ; Reyes, Alexander ; Harris, Kenneth D. / The asynchronous state in cortical circuits. In: Science. 2010 ; Vol. 327, No. 5965. pp. 587-590.
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