The association between cigarette smoking, virologic suppression, and CD4+ lymphocyte count in HIV-Infected Russian women

Jennifer L. Brown, Theresa Winhusen, Ralph DiClemente, Jessica M. Sales, Eve S. Rose, Polina Safonova, Olga Levina, Nikolay Belyakov, Vadim V. Rassokhin

Research output: Contribution to journalArticle

Abstract

Cigarette smoking among people living with HIV/AIDS is associated with significant morbidity and mortality, but findings regarding the association between cigarette smoking and HIV viral load and CD4+ lymphocyte counts have been inconsistent. This study characterized the prevalence of cigarette smoking among HIV-infected Russian women and examined the association between smoking frequency and quantity and HIV viral load and CD4+ lymphocyte counts. HIV-infected Russian women (N = 250; M age = 30.0) in St. Petersburg, Russia, completed an audio computer-assisted self-interview survey assessing cigarette use, antiretroviral medication adherence, and provided blood samples assayed for HIV viral load and CD4+ lymphocyte counts. The majority (60.4%) reported cigarette smoking in the past month; 49.0% of recent smokers were classified as moderate or heavy smokers, defined as smoking ≥10 cigarettes daily. Viral load status did not differ between infrequent smokers and regular smokers. However, moderate/heavy smokers (relative to light smokers) were more likely to have a detectable viral load (AOR = 2.3, 95% CI: 1.1, 5.1). There were no significant differences in CD4+ lymphocyte counts by smoking frequency or quantity of cigarettes smoked. Results highlight the need for additional research to examine the association between cigarette smoking and virologic suppression and markers of HIV disease progression. Adverse health consequences of cigarette smoking coupled with a potential link between heavy smoking and poor virologic suppression highlight the need for assessment of cigarette use and provision of evidence-based smoking-cessation interventions within HIV medical care.

Original languageEnglish (US)
Pages (from-to)1102-1106
Number of pages5
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume29
Issue number9
DOIs
StatePublished - Sep 2 2017

Fingerprint

Lymphocyte Count
suppression
smoking
Smoking
HIV
Viral Load
CD4 Lymphocyte Count
Tobacco Products
Medication Adherence
Needs Assessment
Russia
Smoking Cessation
health consequences
Disease Progression
morbidity
medical care
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
AIDS
medication

Keywords

  • antiretroviral medication adherence
  • Cigarette smoking
  • HIV-infected
  • virologic suppression

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health

Cite this

The association between cigarette smoking, virologic suppression, and CD4+ lymphocyte count in HIV-Infected Russian women. / Brown, Jennifer L.; Winhusen, Theresa; DiClemente, Ralph; Sales, Jessica M.; Rose, Eve S.; Safonova, Polina; Levina, Olga; Belyakov, Nikolay; Rassokhin, Vadim V.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Vol. 29, No. 9, 02.09.2017, p. 1102-1106.

Research output: Contribution to journalArticle

Brown, Jennifer L. ; Winhusen, Theresa ; DiClemente, Ralph ; Sales, Jessica M. ; Rose, Eve S. ; Safonova, Polina ; Levina, Olga ; Belyakov, Nikolay ; Rassokhin, Vadim V. / The association between cigarette smoking, virologic suppression, and CD4+ lymphocyte count in HIV-Infected Russian women. In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV. 2017 ; Vol. 29, No. 9. pp. 1102-1106.
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