The association between 5-HTTLPR gene polymorphism and behavioral inhibition in Chinese toddlers

Xinyin Chen, Guangzhen Zhang, Zongbao Liang, Minghao Zhang, Niobe Way, Hirokazu Yoshikawa, Xiaoyan Ke, Zuhong Lu, Huihua Deng

Research output: Contribution to journalArticle

Abstract

As one of the fundamental individual characteristics, behavioral inhibition in early childhood has considerable implications for the development of social, cognitive, and psychological adjustment. The purpose of this study was to examine the relation between the 5-HTTLPR polymorphism and behavioral inhibition in Chinese children using a cross-sectional design. A sample of 263 2-year-old children (134 boys and 129 girls of Han ethnicity; ages ranging from 24 to 26 months) in China participated in the study. Behavioral inhibition was assessed through laboratory observations, and genomic DNA was collected with buccal swabs. The results of analysis of covariance (ANCOVA) indicated that the homozygous short 5-HTTLPR allele was associated with lower levels of behavioral inhibition, which was different from most of the findings based on individuals in Western countries. The results suggest that social and cultural factors may be involved in shaping links between the 5-HTTLPR polymorphism and children's specific behaviors.

Original languageEnglish (US)
Pages (from-to)1601-1608
Number of pages8
JournalDevelopmental Psychobiology
Volume56
Issue number7
DOIs
StatePublished - Nov 1 2014

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Genes
Social Adjustment
Cheek
Child Behavior
China
Alleles
Inhibition (Psychology)
DNA
Emotional Adjustment

Keywords

  • 5-HTTLPR polymorphism
  • Behavioral inhibition
  • Chinese children

ASJC Scopus subject areas

  • Developmental Biology
  • Behavioral Neuroscience
  • Developmental Neuroscience
  • Developmental and Educational Psychology
  • Medicine(all)

Cite this

The association between 5-HTTLPR gene polymorphism and behavioral inhibition in Chinese toddlers. / Chen, Xinyin; Zhang, Guangzhen; Liang, Zongbao; Zhang, Minghao; Way, Niobe; Yoshikawa, Hirokazu; Ke, Xiaoyan; Lu, Zuhong; Deng, Huihua.

In: Developmental Psychobiology, Vol. 56, No. 7, 01.11.2014, p. 1601-1608.

Research output: Contribution to journalArticle

Chen, Xinyin ; Zhang, Guangzhen ; Liang, Zongbao ; Zhang, Minghao ; Way, Niobe ; Yoshikawa, Hirokazu ; Ke, Xiaoyan ; Lu, Zuhong ; Deng, Huihua. / The association between 5-HTTLPR gene polymorphism and behavioral inhibition in Chinese toddlers. In: Developmental Psychobiology. 2014 ; Vol. 56, No. 7. pp. 1601-1608.
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