The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study

Claire K. Inman, Abdullah Aljunaibi, Hyunwook Koh, Abdishakur Abdulle, Raghib Ali, Abdullah Alnaeemi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al-Maskari, Ayesha Al Dhaheri, Syed M. Shah, Laila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Hosani, Muna Haji, Divya GalaniJiyoung Ahn, Tomas Kirchhoff, Scott Sherman, Richard B. Hayes, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt, Matthew O'Connor

Research output: Contribution to journalArticle

Abstract

Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Clinical and Translational Endocrinology
Volume10
DOIs
StatePublished - Dec 1 2017

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United Arab Emirates
Obesity
Population
Diabetes Mellitus
Waist Circumference
Vitamin D
Type 2 Diabetes Mellitus
Lysine
Hip
Linear Models
Biomarkers
Blood Pressure
Weights and Measures
Serum

Keywords

  • Advanced glycation endproducts (AGEs)
  • Cohort study
  • Diabetes mellitus
  • Obesity
  • Receptor for AGE (RAGE)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The AGE-RAGE axis in an Arab population : The United Arab Emirates Healthy Futures (UAEHFS) pilot study. / Inman, Claire K.; Aljunaibi, Abdullah; Koh, Hyunwook; Abdulle, Abdishakur; Ali, Raghib; Alnaeemi, Abdullah; Al Zaabi, Eiman; Oumeziane, Naima; Al Bastaki, Marina; Al-Houqani, Mohammed; Al-Maskari, Fatma; Al Dhaheri, Ayesha; Shah, Syed M.; Abdel Wareth, Laila; Al Mahmeed, Wael; Alsafar, Habiba; Al Anouti, Fatme; Al Hosani, Ayesha; Haji, Muna; Galani, Divya; Ahn, Jiyoung; Kirchhoff, Tomas; Sherman, Scott; Hayes, Richard B.; Li, Huilin; Ramasamy, Ravichandran; Schmidt, Ann Marie; O'Connor, Matthew.

In: Journal of Clinical and Translational Endocrinology, Vol. 10, 01.12.2017, p. 1-8.

Research output: Contribution to journalArticle

Inman, CK, Aljunaibi, A, Koh, H, Abdulle, A, Ali, R, Alnaeemi, A, Al Zaabi, E, Oumeziane, N, Al Bastaki, M, Al-Houqani, M, Al-Maskari, F, Al Dhaheri, A, Shah, SM, Abdel Wareth, L, Al Mahmeed, W, Alsafar, H, Al Anouti, F, Al Hosani, A, Haji, M, Galani, D, Ahn, J, Kirchhoff, T, Sherman, S, Hayes, RB, Li, H, Ramasamy, R, Schmidt, AM & O'Connor, M 2017, 'The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study', Journal of Clinical and Translational Endocrinology, vol. 10, pp. 1-8. https://doi.org/10.1016/j.jcte.2017.08.001
Inman, Claire K. ; Aljunaibi, Abdullah ; Koh, Hyunwook ; Abdulle, Abdishakur ; Ali, Raghib ; Alnaeemi, Abdullah ; Al Zaabi, Eiman ; Oumeziane, Naima ; Al Bastaki, Marina ; Al-Houqani, Mohammed ; Al-Maskari, Fatma ; Al Dhaheri, Ayesha ; Shah, Syed M. ; Abdel Wareth, Laila ; Al Mahmeed, Wael ; Alsafar, Habiba ; Al Anouti, Fatme ; Al Hosani, Ayesha ; Haji, Muna ; Galani, Divya ; Ahn, Jiyoung ; Kirchhoff, Tomas ; Sherman, Scott ; Hayes, Richard B. ; Li, Huilin ; Ramasamy, Ravichandran ; Schmidt, Ann Marie ; O'Connor, Matthew. / The AGE-RAGE axis in an Arab population : The United Arab Emirates Healthy Futures (UAEHFS) pilot study. In: Journal of Clinical and Translational Endocrinology. 2017 ; Vol. 10. pp. 1-8.
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TY - JOUR

T1 - The AGE-RAGE axis in an Arab population

T2 - The United Arab Emirates Healthy Futures (UAEHFS) pilot study

AU - Inman, Claire K.

AU - Aljunaibi, Abdullah

AU - Koh, Hyunwook

AU - Abdulle, Abdishakur

AU - Ali, Raghib

AU - Alnaeemi, Abdullah

AU - Al Zaabi, Eiman

AU - Oumeziane, Naima

AU - Al Bastaki, Marina

AU - Al-Houqani, Mohammed

AU - Al-Maskari, Fatma

AU - Al Dhaheri, Ayesha

AU - Shah, Syed M.

AU - Abdel Wareth, Laila

AU - Al Mahmeed, Wael

AU - Alsafar, Habiba

AU - Al Anouti, Fatme

AU - Al Hosani, Ayesha

AU - Haji, Muna

AU - Galani, Divya

AU - Ahn, Jiyoung

AU - Kirchhoff, Tomas

AU - Sherman, Scott

AU - Hayes, Richard B.

AU - Li, Huilin

AU - Ramasamy, Ravichandran

AU - Schmidt, Ann Marie

AU - O'Connor, Matthew

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

AB - Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

KW - Advanced glycation endproducts (AGEs)

KW - Cohort study

KW - Diabetes mellitus

KW - Obesity

KW - Receptor for AGE (RAGE)

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