The AGE-RAGE axis in an Arab population

The United Arab Emirates Healthy Futures (UAEHFS) pilot study

Claire K. Inman, Abdullah Aljunaibi, Hyunwook Koh, Abdishakur Abdulle, Raghib Ali, Abdullah Alnaeemi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al-Maskari, Ayesha Al Dhaheri, Syed M. Shah, Laila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Hosani, Muna Haji, Divya Galani & 8 others Matthew J. O'Connor, Jiyoung Ahn, Tomas Kirchhoff, Scott Sherman, Richard B. Hayes, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt

    Research output: Contribution to journalArticle

    Abstract

    Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

    Original languageEnglish (US)
    Pages (from-to)1-8
    Number of pages8
    JournalJournal of Clinical and Translational Endocrinology
    Volume10
    DOIs
    StatePublished - Dec 1 2017

    Fingerprint

    United Arab Emirates
    Obesity
    Population
    Diabetes Mellitus
    Waist Circumference
    Vitamin D
    Type 2 Diabetes Mellitus
    Lysine
    Hip
    Linear Models
    Biomarkers
    Blood Pressure
    Weights and Measures
    Serum

    Keywords

    • Advanced glycation endproducts (AGEs)
    • Cohort study
    • Diabetes mellitus
    • Obesity
    • Receptor for AGE (RAGE)

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

    Cite this

    The AGE-RAGE axis in an Arab population : The United Arab Emirates Healthy Futures (UAEHFS) pilot study. / Inman, Claire K.; Aljunaibi, Abdullah; Koh, Hyunwook; Abdulle, Abdishakur; Ali, Raghib; Alnaeemi, Abdullah; Al Zaabi, Eiman; Oumeziane, Naima; Al Bastaki, Marina; Al-Houqani, Mohammed; Al-Maskari, Fatma; Al Dhaheri, Ayesha; Shah, Syed M.; Abdel Wareth, Laila; Al Mahmeed, Wael; Alsafar, Habiba; Al Anouti, Fatme; Al Hosani, Ayesha; Haji, Muna; Galani, Divya; O'Connor, Matthew J.; Ahn, Jiyoung; Kirchhoff, Tomas; Sherman, Scott; Hayes, Richard B.; Li, Huilin; Ramasamy, Ravichandran; Schmidt, Ann Marie.

    In: Journal of Clinical and Translational Endocrinology, Vol. 10, 01.12.2017, p. 1-8.

    Research output: Contribution to journalArticle

    Inman, CK, Aljunaibi, A, Koh, H, Abdulle, A, Ali, R, Alnaeemi, A, Al Zaabi, E, Oumeziane, N, Al Bastaki, M, Al-Houqani, M, Al-Maskari, F, Al Dhaheri, A, Shah, SM, Abdel Wareth, L, Al Mahmeed, W, Alsafar, H, Al Anouti, F, Al Hosani, A, Haji, M, Galani, D, O'Connor, MJ, Ahn, J, Kirchhoff, T, Sherman, S, Hayes, RB, Li, H, Ramasamy, R & Schmidt, AM 2017, 'The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study', Journal of Clinical and Translational Endocrinology, vol. 10, pp. 1-8. https://doi.org/10.1016/j.jcte.2017.08.001
    Inman, Claire K. ; Aljunaibi, Abdullah ; Koh, Hyunwook ; Abdulle, Abdishakur ; Ali, Raghib ; Alnaeemi, Abdullah ; Al Zaabi, Eiman ; Oumeziane, Naima ; Al Bastaki, Marina ; Al-Houqani, Mohammed ; Al-Maskari, Fatma ; Al Dhaheri, Ayesha ; Shah, Syed M. ; Abdel Wareth, Laila ; Al Mahmeed, Wael ; Alsafar, Habiba ; Al Anouti, Fatme ; Al Hosani, Ayesha ; Haji, Muna ; Galani, Divya ; O'Connor, Matthew J. ; Ahn, Jiyoung ; Kirchhoff, Tomas ; Sherman, Scott ; Hayes, Richard B. ; Li, Huilin ; Ramasamy, Ravichandran ; Schmidt, Ann Marie. / The AGE-RAGE axis in an Arab population : The United Arab Emirates Healthy Futures (UAEHFS) pilot study. In: Journal of Clinical and Translational Endocrinology. 2017 ; Vol. 10. pp. 1-8.
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    abstract = "Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.",
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    T1 - The AGE-RAGE axis in an Arab population

    T2 - The United Arab Emirates Healthy Futures (UAEHFS) pilot study

    AU - Inman, Claire K.

    AU - Aljunaibi, Abdullah

    AU - Koh, Hyunwook

    AU - Abdulle, Abdishakur

    AU - Ali, Raghib

    AU - Alnaeemi, Abdullah

    AU - Al Zaabi, Eiman

    AU - Oumeziane, Naima

    AU - Al Bastaki, Marina

    AU - Al-Houqani, Mohammed

    AU - Al-Maskari, Fatma

    AU - Al Dhaheri, Ayesha

    AU - Shah, Syed M.

    AU - Abdel Wareth, Laila

    AU - Al Mahmeed, Wael

    AU - Alsafar, Habiba

    AU - Al Anouti, Fatme

    AU - Al Hosani, Ayesha

    AU - Haji, Muna

    AU - Galani, Divya

    AU - O'Connor, Matthew J.

    AU - Ahn, Jiyoung

    AU - Kirchhoff, Tomas

    AU - Sherman, Scott

    AU - Hayes, Richard B.

    AU - Li, Huilin

    AU - Ramasamy, Ravichandran

    AU - Schmidt, Ann Marie

    PY - 2017/12/1

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    N2 - Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

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    KW - Advanced glycation endproducts (AGEs)

    KW - Cohort study

    KW - Diabetes mellitus

    KW - Obesity

    KW - Receptor for AGE (RAGE)

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