The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study

Claire K. Inman, Abdullah Aljunaibi, Hyunwook Koh, Abdishakur Abdulle, Raghib Ali, Abdullah Alnaeemi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al-Maskari, Ayesha Al Dhaheri, Syed M. Shah, Laila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Hosani, Muna Haji, Divya GalaniJiyoung Ahn, Tomas Kirchhoff, Scott Sherman, Richard B. Hayes, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt, Matthew O'Connor

Research output: Contribution to journalArticle

Abstract

Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Clinical and Translational Endocrinology
Volume10
DOIs
StatePublished - Dec 2017

Keywords

  • Advanced glycation endproducts (AGEs)
  • Cohort study
  • Diabetes mellitus
  • Obesity
  • Receptor for AGE (RAGE)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Inman, C. K., Aljunaibi, A., Koh, H., Abdulle, A., Ali, R., Alnaeemi, A., Al Zaabi, E., Oumeziane, N., Al Bastaki, M., Al-Houqani, M., Al-Maskari, F., Al Dhaheri, A., Shah, S. M., Abdel Wareth, L., Al Mahmeed, W., Alsafar, H., Al Anouti, F., Al Hosani, A., Haji, M., ... O'Connor, M. (2017). The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study. Journal of Clinical and Translational Endocrinology, 10, 1-8. https://doi.org/10.1016/j.jcte.2017.08.001